Protein kinase C and cancer: what we know and what we do not

Since their discovery in the late 1970s, protein kinase C (PKC) isozymes represent one of the most extensively studied signaling kinases. PKCs signal through multiple pathways and control the expression of genes relevant for cell cycle progression, tumorigenesis and metastatic dissemination. Despite...

Descripción completa

Guardado en:
Detalles Bibliográficos
Autores principales: Garg, R., Benedetti, L.G., Abera, M. B., Wang, H., Abba, Martín Carlos, Kazanietz, M.G.
Formato: Articulo Revision
Lenguaje:Inglés
Publicado: 2014
Materias:
Ciencias Médicas
Animal models
Apoptosis
Metastasis
Protein kinase C (PKC)
Survival
Tumorigenesis
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/85265
Aporte de:
SEDICI (UNLP) de Universidad Nacional de La Plata
id I19-R120-10915-85265
record_format dspace
institution Universidad Nacional de La Plata
institution_str I-19
repository_str R-120
collection SEDICI (UNLP)
language Inglés
topic Ciencias Médicas
Animal models
Apoptosis
Metastasis
Protein kinase C (PKC)
Survival
Tumorigenesis
spellingShingle Ciencias Médicas
Animal models
Apoptosis
Metastasis
Protein kinase C (PKC)
Survival
Tumorigenesis
Garg, R.
Benedetti, L.G.
Abera, M. B.
Wang, H.
Abba, Martín Carlos
Kazanietz, M.G.
Protein kinase C and cancer: what we know and what we do not
topic_facet Ciencias Médicas
Animal models
Apoptosis
Metastasis
Protein kinase C (PKC)
Survival
Tumorigenesis
description Since their discovery in the late 1970s, protein kinase C (PKC) isozymes represent one of the most extensively studied signaling kinases. PKCs signal through multiple pathways and control the expression of genes relevant for cell cycle progression, tumorigenesis and metastatic dissemination. Despite the vast amount of information concerning the mechanisms that control PKC activation and function in cellular models, the relevance of individual PKC isozymes in the progression of human cancer is still a matter of controversy. Although the expression of PKC isozymes is altered in multiple cancer types, the causal relationship between such changes and the initiation and progression of the disease remains poorly defined. Animal models developed in the last years helped to better understand the involvement of individual PKCs in various cancer types and in the context of specific oncogenic alterations. Unraveling the enormous complexity in the mechanisms by which PKC isozymes have an impact on tumorigenesis and metastasis is key for reassessing their potential as pharmacological targets for cancer treatment.
format Articulo
Revision
author Garg, R.
Benedetti, L.G.
Abera, M. B.
Wang, H.
Abba, Martín Carlos
Kazanietz, M.G.
author_facet Garg, R.
Benedetti, L.G.
Abera, M. B.
Wang, H.
Abba, Martín Carlos
Kazanietz, M.G.
author_sort Garg, R.
title Protein kinase C and cancer: what we know and what we do not
title_short Protein kinase C and cancer: what we know and what we do not
title_full Protein kinase C and cancer: what we know and what we do not
title_fullStr Protein kinase C and cancer: what we know and what we do not
title_full_unstemmed Protein kinase C and cancer: what we know and what we do not
title_sort protein kinase c and cancer: what we know and what we do not
publishDate 2014
url http://sedici.unlp.edu.ar/handle/10915/85265
work_keys_str_mv AT gargr proteinkinasecandcancerwhatweknowandwhatwedonot
AT benedettilg proteinkinasecandcancerwhatweknowandwhatwedonot
AT aberamb proteinkinasecandcancerwhatweknowandwhatwedonot
AT wangh proteinkinasecandcancerwhatweknowandwhatwedonot
AT abbamartincarlos proteinkinasecandcancerwhatweknowandwhatwedonot
AT kazanietzmg proteinkinasecandcancerwhatweknowandwhatwedonot
bdutipo_str Repositorios
_version_ 1764820489169010690

Ejemplares similares