L925I Mutation in the Para-Type Sodium Channel Is Associated with Pyrethroid Resistance in Triatoma infestans from the Gran Chaco Region

Background:Chagas' disease is an important public health concern in Latin America. Despite intensive vector control efforts using pyrethroid insecticides, the elimination of Triatoma infestans has failed in the Gran Chaco, an ecoregion that extends over Argentina, Paraguay, Bolivia and Brazil.T...

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Autores principales: Capriotti, Natalia, Mougabure Cueto, G., Rivera Pomar, Rolando Víctor, Ons, Sheila
Formato: Articulo
Lenguaje:Inglés
Publicado: 2014
Materias:
Ciencias Exactas
Triatoma
Sodio
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/85261
Aporte de:
SEDICI (UNLP) de Universidad Nacional de La Plata
id I19-R120-10915-85261
record_format dspace
institution Universidad Nacional de La Plata
institution_str I-19
repository_str R-120
collection SEDICI (UNLP)
language Inglés
topic Ciencias Exactas
Triatoma
Sodio
spellingShingle Ciencias Exactas
Triatoma
Sodio
Capriotti, Natalia
Mougabure Cueto, G.
Rivera Pomar, Rolando Víctor
Ons, Sheila
L925I Mutation in the Para-Type Sodium Channel Is Associated with Pyrethroid Resistance in Triatoma infestans from the Gran Chaco Region
topic_facet Ciencias Exactas
Triatoma
Sodio
description Background:Chagas' disease is an important public health concern in Latin America. Despite intensive vector control efforts using pyrethroid insecticides, the elimination of Triatoma infestans has failed in the Gran Chaco, an ecoregion that extends over Argentina, Paraguay, Bolivia and Brazil.The voltage-gated sodium channel is the target site of pyrethroid insecticides. Point mutations in domain II region of the channel have been implicated in pyrethroid resistance of several insect species.Methods and Findings:In the present paper, we identify L925I, a new pyrethroid resistance-conferring mutation in T. infestans. This mutation has been found only in hemipterans. In T. infestans, L925I mutation occurs in a resistant population from the Gran Chaco region and is associated with inefficiency in the control campaigns. We also describe a method to detect L925I mutation in individuals from the field.Conclusions and Significance:The findings have important implications in the implementation of strategies for resistance management and in the rational design of campaigns for the control of Chagas' disease transmission.
format Articulo
Articulo
author Capriotti, Natalia
Mougabure Cueto, G.
Rivera Pomar, Rolando Víctor
Ons, Sheila
author_facet Capriotti, Natalia
Mougabure Cueto, G.
Rivera Pomar, Rolando Víctor
Ons, Sheila
author_sort Capriotti, Natalia
title L925I Mutation in the Para-Type Sodium Channel Is Associated with Pyrethroid Resistance in Triatoma infestans from the Gran Chaco Region
title_short L925I Mutation in the Para-Type Sodium Channel Is Associated with Pyrethroid Resistance in Triatoma infestans from the Gran Chaco Region
title_full L925I Mutation in the Para-Type Sodium Channel Is Associated with Pyrethroid Resistance in Triatoma infestans from the Gran Chaco Region
title_fullStr L925I Mutation in the Para-Type Sodium Channel Is Associated with Pyrethroid Resistance in Triatoma infestans from the Gran Chaco Region
title_full_unstemmed L925I Mutation in the Para-Type Sodium Channel Is Associated with Pyrethroid Resistance in Triatoma infestans from the Gran Chaco Region
title_sort l925i mutation in the para-type sodium channel is associated with pyrethroid resistance in triatoma infestans from the gran chaco region
publishDate 2014
url http://sedici.unlp.edu.ar/handle/10915/85261
work_keys_str_mv AT capriottinatalia l925imutationintheparatypesodiumchannelisassociatedwithpyrethroidresistanceintriatomainfestansfromthegranchacoregion
AT mougaburecuetog l925imutationintheparatypesodiumchannelisassociatedwithpyrethroidresistanceintriatomainfestansfromthegranchacoregion
AT riverapomarrolandovictor l925imutationintheparatypesodiumchannelisassociatedwithpyrethroidresistanceintriatomainfestansfromthegranchacoregion
AT onssheila l925imutationintheparatypesodiumchannelisassociatedwithpyrethroidresistanceintriatomainfestansfromthegranchacoregion
bdutipo_str Repositorios
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