Antioxidant activity and cardioprotective effect of a nonalcoholic extract of Vaccinium meridionale Swartz during ischemia-reperfusion in rats

Our objective was to assess the antioxidant properties and the effects against the reperfusion injury of a nonalcoholic extract obtained by fermentation from the Colombian blueberry, mortiño (<i>Vaccinium meridionale</i> Swartz, Ericaceae). Antioxidant properties were assessed by <i&g...

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Detalles Bibliográficos
Autores principales: Lopera, Yasmin E., Fantinelli, Juliana Catalina, González Arbeláez, Luisa Fernanda, Rojano, Benjamín, Ríos, José Luis, Schinella, Guillermo Raúl, Mosca, Susana María
Formato: Articulo
Lenguaje:Inglés
Publicado: 2013
Materias:
Ciencias Médicas
Anthocyanins
Juices
Anthocyanin degradation
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/85231
Aporte de:
SEDICI (UNLP) de Universidad Nacional de La Plata
id I19-R120-10915-85231
record_format dspace
institution Universidad Nacional de La Plata
institution_str I-19
repository_str R-120
collection SEDICI (UNLP)
language Inglés
topic Ciencias Médicas
Anthocyanins
Juices
Anthocyanin degradation
spellingShingle Ciencias Médicas
Anthocyanins
Juices
Anthocyanin degradation
Lopera, Yasmin E.
Fantinelli, Juliana Catalina
González Arbeláez, Luisa Fernanda
Rojano, Benjamín
Ríos, José Luis
Schinella, Guillermo Raúl
Mosca, Susana María
Antioxidant activity and cardioprotective effect of a nonalcoholic extract of Vaccinium meridionale Swartz during ischemia-reperfusion in rats
topic_facet Ciencias Médicas
Anthocyanins
Juices
Anthocyanin degradation
description Our objective was to assess the antioxidant properties and the effects against the reperfusion injury of a nonalcoholic extract obtained by fermentation from the Colombian blueberry, mortiño (<i>Vaccinium meridionale</i> Swartz, Ericaceae). Antioxidant properties were assessed by <i>in vitro</i> systems. To examine the postischemic myocardial function, isolated rat hearts were treated 10 min before ischemia and during the first 10 min of reperfusion with the extract. To analyze the participation of nitric oxide (NO), other experiments were performed in the presence of nitric oxide synthase (NOS) inhibition with N<SUP>G</SUP>-nitro-L-arginine methyl ester (L-NAME). In cardiac tissue thiobarbituric acid reactive substances (TBARS) concentration, reduced glutathione (GSH) content, endothelial NOS (eNOS), and Akt expression were also measured. The blueberry extract showed higher total phenols and anthocyanins contents, scavenging activity of superoxide radical and systolic and diastolic function was improved, TBARS diminished, GSH was partially preserved, and both NOS and Akt expression increased in hearts treated with the extract. These beneficial effects were lost when eNOS was inhibited. In resume, these data show that the increase of eNOS expression via Akt and the scavenging activity contribute to the cardioprotection afforded by acute treatment with Colombian blueberry extract against ischemia and reperfusion injury.
format Articulo
Articulo
author Lopera, Yasmin E.
Fantinelli, Juliana Catalina
González Arbeláez, Luisa Fernanda
Rojano, Benjamín
Ríos, José Luis
Schinella, Guillermo Raúl
Mosca, Susana María
author_facet Lopera, Yasmin E.
Fantinelli, Juliana Catalina
González Arbeláez, Luisa Fernanda
Rojano, Benjamín
Ríos, José Luis
Schinella, Guillermo Raúl
Mosca, Susana María
author_sort Lopera, Yasmin E.
title Antioxidant activity and cardioprotective effect of a nonalcoholic extract of Vaccinium meridionale Swartz during ischemia-reperfusion in rats
title_short Antioxidant activity and cardioprotective effect of a nonalcoholic extract of Vaccinium meridionale Swartz during ischemia-reperfusion in rats
title_full Antioxidant activity and cardioprotective effect of a nonalcoholic extract of Vaccinium meridionale Swartz during ischemia-reperfusion in rats
title_fullStr Antioxidant activity and cardioprotective effect of a nonalcoholic extract of Vaccinium meridionale Swartz during ischemia-reperfusion in rats
title_full_unstemmed Antioxidant activity and cardioprotective effect of a nonalcoholic extract of Vaccinium meridionale Swartz during ischemia-reperfusion in rats
title_sort antioxidant activity and cardioprotective effect of a nonalcoholic extract of vaccinium meridionale swartz during ischemia-reperfusion in rats
publishDate 2013
url http://sedici.unlp.edu.ar/handle/10915/85231
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