Na+-H+ exchanger inhibition : A new antihypertrophic tool

Cardiac hypertrophy (CH) is a major risk factor for cardiac death and commonly precedes the development of heart failure (HF). This is motivating the search for novel pharmacological strategies to prevent the development and/or regress CH. Although the signaling pathways leading to myocardial hypert...

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Detalles Bibliográficos
Autores principales: Cingolani, Horacio Eugenio, Camilión de Hurtado, María Cristina
Formato: Articulo
Lenguaje:Inglés
Publicado: 2002
Materias:
Ciencias Médicas
Cardiac hypertrophy
Na+-H+ exchanger
NHE1 inhibitors
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/84978
Aporte de:
SEDICI (UNLP) de Universidad Nacional de La Plata
id I19-R120-10915-84978
record_format dspace
institution Universidad Nacional de La Plata
institution_str I-19
repository_str R-120
collection SEDICI (UNLP)
language Inglés
topic Ciencias Médicas
Cardiac hypertrophy
Na+-H+ exchanger
NHE1 inhibitors
spellingShingle Ciencias Médicas
Cardiac hypertrophy
Na+-H+ exchanger
NHE1 inhibitors
Cingolani, Horacio Eugenio
Camilión de Hurtado, María Cristina
Na+-H+ exchanger inhibition : A new antihypertrophic tool
topic_facet Ciencias Médicas
Cardiac hypertrophy
Na+-H+ exchanger
NHE1 inhibitors
description Cardiac hypertrophy (CH) is a major risk factor for cardiac death and commonly precedes the development of heart failure (HF). This is motivating the search for novel pharmacological strategies to prevent the development and/or regress CH. Although the signaling pathways leading to myocardial hypertrophy are complex, one important set of pathways involves the mitogen-activated protein kinases (MAPKs). MAPKs phosphorylate numerous substrates, including nuclear transcription factors that activate the expression of different genes. The Na<SUP>+</SUP>-H<SUP>+</SUP> exchanger (NHE) is a common downstream effector of this cascade and has been implicated in different models of hypertrophy, such as “hypertensive” myocardium, aortic constrictioninduced hypertrophy, and postinfarction myocardial hypertrophy. Interestingly, stretch-induced hypertrophy of cultured neonatal cardiomyocytes is also accompanied by an increase in MAPK activity and NHE activation. Furthermore, stretch-induced MAPK stimulation is partially prevented by inhibition of NHE activity.
format Articulo
Articulo
author Cingolani, Horacio Eugenio
Camilión de Hurtado, María Cristina
author_facet Cingolani, Horacio Eugenio
Camilión de Hurtado, María Cristina
author_sort Cingolani, Horacio Eugenio
title Na+-H+ exchanger inhibition : A new antihypertrophic tool
title_short Na+-H+ exchanger inhibition : A new antihypertrophic tool
title_full Na+-H+ exchanger inhibition : A new antihypertrophic tool
title_fullStr Na+-H+ exchanger inhibition : A new antihypertrophic tool
title_full_unstemmed Na+-H+ exchanger inhibition : A new antihypertrophic tool
title_sort na+-h+ exchanger inhibition : a new antihypertrophic tool
publishDate 2002
url http://sedici.unlp.edu.ar/handle/10915/84978
work_keys_str_mv AT cingolanihoracioeugenio nahexchangerinhibitionanewantihypertrophictool
AT camiliondehurtadomariacristina nahexchangerinhibitionanewantihypertrophictool
bdutipo_str Repositorios
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