Assessment of pertussis vaccination strategies using a mathematical model of disease transmission
Pertussis or whooping cough is a vaccinepreventable respiratory disease that has reemerged in the past decades. A higher morbidity and mortality has been recorded in infants, although cases have also been reported in adolescents and adults. The epidemiological scenario for this condition has urged t...
Guardado en:
| Autores principales: | , , , |
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| Formato: | Articulo |
| Lenguaje: | Inglés |
| Publicado: |
2013
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| Acceso en línea: | http://sedici.unlp.edu.ar/handle/10915/84945 |
| Aporte de: |
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I19-R120-10915-84945 |
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| record_format |
dspace |
| institution |
Universidad Nacional de La Plata |
| institution_str |
I-19 |
| repository_str |
R-120 |
| collection |
SEDICI (UNLP) |
| language |
Inglés |
| topic |
Biología Booster Bordetella pertussis Immunization Model Pertussis Pertussis vaccine |
| spellingShingle |
Biología Booster Bordetella pertussis Immunization Model Pertussis Pertussis vaccine Pesco, Pablo Sebastián Bergero, Paula Elena Fabricius, Gabriel Hozbor, Daniela Flavia Assessment of pertussis vaccination strategies using a mathematical model of disease transmission |
| topic_facet |
Biología Booster Bordetella pertussis Immunization Model Pertussis Pertussis vaccine |
| description |
Pertussis or whooping cough is a vaccinepreventable respiratory disease that has reemerged in the past decades. A higher morbidity and mortality has been recorded in infants, although cases have also been reported in adolescents and adults. The epidemiological scenario for this condition has urged to review and implement new strategies aimed at improving its control. However, many of these strategies have not been investigated in depth so as to be established as universal. In this context, mathematical models of disease transmission are useful decisionmaking tools. Using a mathematical model of pertussis, this study assessed the possible impact of the different control measures on the most vulnerable population (0-1 year old infants). In particular, the analysis focused on the impact of including a booster vaccination at 11 years old, the effect of improving the coverage provided by primary doses, and the reduction of any delay in their administration. The assessment also estimated the effect of immunizing pregnant women. Results show that including a booster dose at 11 years reduces the incidence of pertussis by 3% in infants younger than 1 year old. In addition, administering primary doses in compliance with the schedule (with no delays) reduces pertussis incidence by 16%. Increasing coverage from 80% to 95% results in a significantly decreased incidence in the vulnerable population (38%). If the percentage of immunized pregnant women reaches 50%, the reduction of the most severe infant cases could be more than 43% (0-2 monthold infants). |
| format |
Articulo Articulo |
| author |
Pesco, Pablo Sebastián Bergero, Paula Elena Fabricius, Gabriel Hozbor, Daniela Flavia |
| author_facet |
Pesco, Pablo Sebastián Bergero, Paula Elena Fabricius, Gabriel Hozbor, Daniela Flavia |
| author_sort |
Pesco, Pablo Sebastián |
| title |
Assessment of pertussis vaccination strategies using a mathematical model of disease transmission |
| title_short |
Assessment of pertussis vaccination strategies using a mathematical model of disease transmission |
| title_full |
Assessment of pertussis vaccination strategies using a mathematical model of disease transmission |
| title_fullStr |
Assessment of pertussis vaccination strategies using a mathematical model of disease transmission |
| title_full_unstemmed |
Assessment of pertussis vaccination strategies using a mathematical model of disease transmission |
| title_sort |
assessment of pertussis vaccination strategies using a mathematical model of disease transmission |
| publishDate |
2013 |
| url |
http://sedici.unlp.edu.ar/handle/10915/84945 |
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Repositorios |
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