Bordetella pertussis entry into respiratory epithelial cells and intracellular survival

Bordetella pertussis is the causative agent of pertussis, aka whooping cough. Although generally considered an extracellular pathogen, this bacterium has been found inside respiratory epithelial cells, which might represent a survival strategy inside the host. Relatively little is known, however, ab...

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Autores principales: Lamberti, Yanina Andrea, Gorgojo, Juan Pablo, Massillo, Cintia, Rodríguez, María Eugenia
Formato: Articulo
Lenguaje:Inglés
Publicado: 2013
Materias:
Química
Bacterial persistence
Bordetella pertussis
Respiratory epithelial cells
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/84934
Aporte de:
SEDICI (UNLP) de Universidad Nacional de La Plata
id I19-R120-10915-84934
record_format dspace
institution Universidad Nacional de La Plata
institution_str I-19
repository_str R-120
collection SEDICI (UNLP)
language Inglés
topic Química
Bacterial persistence
Bordetella pertussis
Respiratory epithelial cells
spellingShingle Química
Bacterial persistence
Bordetella pertussis
Respiratory epithelial cells
Lamberti, Yanina Andrea
Gorgojo, Juan Pablo
Massillo, Cintia
Rodríguez, María Eugenia
Bordetella pertussis entry into respiratory epithelial cells and intracellular survival
topic_facet Química
Bacterial persistence
Bordetella pertussis
Respiratory epithelial cells
description Bordetella pertussis is the causative agent of pertussis, aka whooping cough. Although generally considered an extracellular pathogen, this bacterium has been found inside respiratory epithelial cells, which might represent a survival strategy inside the host. Relatively little is known, however, about the mechanism of internalization and the fate of B. pertussis inside the epithelia. We show here that B. pertussis is able to enter those cells by a mechanism dependent on microtubule assembly, lipid raft integrity, and the activation of a tyrosine-kinase-mediated signaling. Once inside the cell, a significant proportion of the intracellular bacteria evade phagolysosomal fusion and remain viable in nonacidic lysosome-associated membrane-protein-1-negative compartments. In addition, intracellular B. pertussis was found able to repopulate the extracellular environment after complete elimination of the extracellular bacteria with polymyxin B. Taken together, these data suggest that B. pertussis is able to survive within respiratory epithelial cells and by this means potentially contribute to host immune system evasion.
format Articulo
Articulo
author Lamberti, Yanina Andrea
Gorgojo, Juan Pablo
Massillo, Cintia
Rodríguez, María Eugenia
author_facet Lamberti, Yanina Andrea
Gorgojo, Juan Pablo
Massillo, Cintia
Rodríguez, María Eugenia
author_sort Lamberti, Yanina Andrea
title Bordetella pertussis entry into respiratory epithelial cells and intracellular survival
title_short Bordetella pertussis entry into respiratory epithelial cells and intracellular survival
title_full Bordetella pertussis entry into respiratory epithelial cells and intracellular survival
title_fullStr Bordetella pertussis entry into respiratory epithelial cells and intracellular survival
title_full_unstemmed Bordetella pertussis entry into respiratory epithelial cells and intracellular survival
title_sort bordetella pertussis entry into respiratory epithelial cells and intracellular survival
publishDate 2013
url http://sedici.unlp.edu.ar/handle/10915/84934
work_keys_str_mv AT lambertiyaninaandrea bordetellapertussisentryintorespiratoryepithelialcellsandintracellularsurvival
AT gorgojojuanpablo bordetellapertussisentryintorespiratoryepithelialcellsandintracellularsurvival
AT massillocintia bordetellapertussisentryintorespiratoryepithelialcellsandintracellularsurvival
AT rodriguezmariaeugenia bordetellapertussisentryintorespiratoryepithelialcellsandintracellularsurvival
bdutipo_str Repositorios
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