Abnormal expression of apoptosis-related genes in haematological malignancies: Overexpression of MYC is poor prognostic sign in mantle cell lymphoma

The expression of apoptosis-related genes BCL2, BAX, BCL2L1, BCL2A1, MCL1, DAPK1 and MYC was studied by quantitative real-time polymerase chain reaction on total RNA samples from patients with acute lymphoblastic leukaemia (ALL, n = 16), acute myeloid leukaemia (AML, n = 27). chronic myeloid leukaem...

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Autores principales: Nagy, Bálint, Lundán, Tuija, Larramendy, Marcelo Luis, Aalto, Yan, Zhu, Ying, Niini, Tarja, Edgren, Henrik, Ferrer, Anna, Vilpo, Juhani, Elonen, Erkki, Vettenranta, Kim, Franssila, Kaarle, Knuutila, Sakari
Formato: Articulo
Lenguaje:Inglés
Publicado: 2003
Materias:
Ciencias Naturales
Apoptotic genes
Gene expression
Haematological malignancies
Prognosis
Quantitative real-time PCR
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/84918
Aporte de:
SEDICI (UNLP) de Universidad Nacional de La Plata
id I19-R120-10915-84918
record_format dspace
institution Universidad Nacional de La Plata
institution_str I-19
repository_str R-120
collection SEDICI (UNLP)
language Inglés
topic Ciencias Naturales
Apoptotic genes
Gene expression
Haematological malignancies
Prognosis
Quantitative real-time PCR
spellingShingle Ciencias Naturales
Apoptotic genes
Gene expression
Haematological malignancies
Prognosis
Quantitative real-time PCR
Nagy, Bálint
Lundán, Tuija
Larramendy, Marcelo Luis
Aalto, Yan
Zhu, Ying
Niini, Tarja
Edgren, Henrik
Ferrer, Anna
Vilpo, Juhani
Elonen, Erkki
Vettenranta, Kim
Franssila, Kaarle
Knuutila, Sakari
Abnormal expression of apoptosis-related genes in haematological malignancies: Overexpression of MYC is poor prognostic sign in mantle cell lymphoma
topic_facet Ciencias Naturales
Apoptotic genes
Gene expression
Haematological malignancies
Prognosis
Quantitative real-time PCR
description The expression of apoptosis-related genes BCL2, BAX, BCL2L1, BCL2A1, MCL1, DAPK1 and MYC was studied by quantitative real-time polymerase chain reaction on total RNA samples from patients with acute lymphoblastic leukaemia (ALL, n = 16), acute myeloid leukaemia (AML, n = 27). chronic myeloid leukaemia (CML, n = 12), mantle cell lymphoma (MCL, n = 19) and chronic lymphoid leukaemia (CLL. n = 32). BCL2, BAX, BCL2A1, MCL1, DAPK1 and MYC were overexpressed in all patient groups. BCL2L1 was underexpressed in CLL and CML, but not in AML, ALL and MCL. MCL1 levels were significantly higher in CD13 and CD33-positive ALL, and in CD56-positive AML samples. BCL2, BCL2L1, BCL2A1 and MCL1 were overexpressed and DAPK1 was underexpressed in CLL samples with a 11q23 deletion. MYC overexpression was significantly associated with shorter overall survival in MCL (P ≤ 0.01). AML patients with a normal karyotype showed a higher frequency of BCL2A1 overexpression (P ≤ 0.001) than those with an abnormal karyotype.
format Articulo
Articulo
author Nagy, Bálint
Lundán, Tuija
Larramendy, Marcelo Luis
Aalto, Yan
Zhu, Ying
Niini, Tarja
Edgren, Henrik
Ferrer, Anna
Vilpo, Juhani
Elonen, Erkki
Vettenranta, Kim
Franssila, Kaarle
Knuutila, Sakari
author_facet Nagy, Bálint
Lundán, Tuija
Larramendy, Marcelo Luis
Aalto, Yan
Zhu, Ying
Niini, Tarja
Edgren, Henrik
Ferrer, Anna
Vilpo, Juhani
Elonen, Erkki
Vettenranta, Kim
Franssila, Kaarle
Knuutila, Sakari
author_sort Nagy, Bálint
title Abnormal expression of apoptosis-related genes in haematological malignancies: Overexpression of MYC is poor prognostic sign in mantle cell lymphoma
title_short Abnormal expression of apoptosis-related genes in haematological malignancies: Overexpression of MYC is poor prognostic sign in mantle cell lymphoma
title_full Abnormal expression of apoptosis-related genes in haematological malignancies: Overexpression of MYC is poor prognostic sign in mantle cell lymphoma
title_fullStr Abnormal expression of apoptosis-related genes in haematological malignancies: Overexpression of MYC is poor prognostic sign in mantle cell lymphoma
title_full_unstemmed Abnormal expression of apoptosis-related genes in haematological malignancies: Overexpression of MYC is poor prognostic sign in mantle cell lymphoma
title_sort abnormal expression of apoptosis-related genes in haematological malignancies: overexpression of myc is poor prognostic sign in mantle cell lymphoma
publishDate 2003
url http://sedici.unlp.edu.ar/handle/10915/84918
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