Augmented serum levels of the IGF-I/IGF-binding protein-3 ratio in pre-menopausal patients with type I breast cysts
Objective: Gross cystic disease (GCD) is the most common benign breast pathology. Although breast cysts are not considered pre-malignant lesions, an increased risk of breast cancer has been reported for patients with type I cysts (Na<SUP>+</SUP>/K<SUP>+</SUP> < 3). Further...
| Autores principales: | , , , , , |
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| Formato: | Articulo |
| Lenguaje: | Inglés |
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2003
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| Acceso en línea: | http://sedici.unlp.edu.ar/handle/10915/84877 |
| Aporte de: |
| id |
I19-R120-10915-84877 |
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| record_format |
dspace |
| institution |
Universidad Nacional de La Plata |
| institution_str |
I-19 |
| repository_str |
R-120 |
| collection |
SEDICI (UNLP) |
| language |
Inglés |
| topic |
Ciencias Exactas Ciencias Médicas breast cancer pre-menopausal patients serum levels |
| spellingShingle |
Ciencias Exactas Ciencias Médicas breast cancer pre-menopausal patients serum levels Enriori, Pablo J. Fischer, Carlos R. Gori, Jorge R. Etkin, Alberto E. Calandra, Ricardo Saúl Lüthy, Isabel A. Augmented serum levels of the IGF-I/IGF-binding protein-3 ratio in pre-menopausal patients with type I breast cysts |
| topic_facet |
Ciencias Exactas Ciencias Médicas breast cancer pre-menopausal patients serum levels |
| description |
Objective: Gross cystic disease (GCD) is the most common benign breast pathology. Although breast cysts are not considered pre-malignant lesions, an increased risk of breast cancer has been reported for patients with type I cysts (Na<SUP>+</SUP>/K<SUP>+</SUP> < 3). Furthermore, an augmented IGF-I/IGF-binding protein-3 (IGFBP-3) ratio has been described in breast cancer patients. The objective was to evaluate serum IGF-I and binding protein concentrations of type I and type II cyst patients as compared with healthy women.
Methods: Twenty-four patients with type I cysts, 17 with type II cysts and 25 healthy women were evaluated. Serum IGF-I, IGFBP-3 and IGFBP-1 concentrations were measured by IRMA.
Results: IGF-I concentrations were significantly higher in sera from patients with type I cysts than in patients with type II cysts. A highly significant decrease of IGFBP-3, the major IGFBP, was found in patients with type I cysts with respect to healthy women, whereas no significant difference was evident between the different cyst types. The IGF-I/IGFBP-3 ratio, an estimate of biologically active IGF-I, was very significantly higher in patients with type I cysts than in both type II patients and healthy women. IGFBP-1 levels were significantly lower in patients with type I than in controls and type II cysts. The IGF-I/IGFBP-1 ratio was significantly higher in patients with type I cysts than in type II bearers and healthy women. Estrogen levels correlated with IGF-I in patients and controls.
Conclusions: The enhanced levels of IGF-I/IGFBP-3 found in patients with type I cysts could eventually be associated with the increased risk of breast cancer described for this group. |
| format |
Articulo Articulo |
| author |
Enriori, Pablo J. Fischer, Carlos R. Gori, Jorge R. Etkin, Alberto E. Calandra, Ricardo Saúl Lüthy, Isabel A. |
| author_facet |
Enriori, Pablo J. Fischer, Carlos R. Gori, Jorge R. Etkin, Alberto E. Calandra, Ricardo Saúl Lüthy, Isabel A. |
| author_sort |
Enriori, Pablo J. |
| title |
Augmented serum levels of the IGF-I/IGF-binding protein-3 ratio in pre-menopausal patients with type I breast cysts |
| title_short |
Augmented serum levels of the IGF-I/IGF-binding protein-3 ratio in pre-menopausal patients with type I breast cysts |
| title_full |
Augmented serum levels of the IGF-I/IGF-binding protein-3 ratio in pre-menopausal patients with type I breast cysts |
| title_fullStr |
Augmented serum levels of the IGF-I/IGF-binding protein-3 ratio in pre-menopausal patients with type I breast cysts |
| title_full_unstemmed |
Augmented serum levels of the IGF-I/IGF-binding protein-3 ratio in pre-menopausal patients with type I breast cysts |
| title_sort |
augmented serum levels of the igf-i/igf-binding protein-3 ratio in pre-menopausal patients with type i breast cysts |
| publishDate |
2003 |
| url |
http://sedici.unlp.edu.ar/handle/10915/84877 |
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