Global population structure and evolution of Bordetella pertussis and their relationship with vaccination

Bordetella pertussis causes pertussis, a respiratory disease that is most severe for infants. Vaccination was introduced in the 1950s, and in recent years, a resurgence of disease was observed worldwide, with significant mortality in infants. Possible causes for this include the switch from whole-ce...

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Autores principales: Bottero, Daniela, Gaillard, María Emilia, Hozbor, Daniela Flavia
Formato: Articulo
Lenguaje:Inglés
Publicado: 2014
Materias:
Biología
Bordetella pertussis
Vaccination
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/84867
Aporte de:
SEDICI (UNLP) de Universidad Nacional de La Plata
id I19-R120-10915-84867
record_format dspace
institution Universidad Nacional de La Plata
institution_str I-19
repository_str R-120
collection SEDICI (UNLP)
language Inglés
topic Biología
Bordetella pertussis
Vaccination
spellingShingle Biología
Bordetella pertussis
Vaccination
Bottero, Daniela
Gaillard, María Emilia
Hozbor, Daniela Flavia
Global population structure and evolution of Bordetella pertussis and their relationship with vaccination
topic_facet Biología
Bordetella pertussis
Vaccination
description Bordetella pertussis causes pertussis, a respiratory disease that is most severe for infants. Vaccination was introduced in the 1950s, and in recent years, a resurgence of disease was observed worldwide, with significant mortality in infants. Possible causes for this include the switch from whole-cell vaccines (WCVs) to less effective acellular vaccines (ACVs), waning immunity, and pathogen adaptation. Pathogen adaptation is suggested by antigenic divergence between vaccine strains and circulating strains and by the emergence of strains with increased pertussis toxin production. We applied comparative genomics to a worldwide collection of 343 B. pertussis strains isolated between 1920 and 2010. The global phylogeny showed two deep branches; the largest of these contained 98% of all strains, and its expansion correlated temporally with the first descriptions of pertussis outbreaks in Europe in the 16th century. We found little evidence of recent geographical clustering of the strains within this lineage, suggesting rapid strain flow between countries. We observed that changes in genes encoding proteins implicated in protective immunity that are included in ACVs occurred after the introduction of WCVs but before the switch to ACVs. Furthermore, our analyses consistently suggested that virulence-associated genes and genes coding for surface-exposed proteins were involved in adaptation. However, many of the putative adaptive loci identified have a physiological role, and further studies of these loci may reveal less obvious ways in which B. pertussis and the host interact. This work provides insight into ways in which pathogens may adapt to vaccination and suggests ways to improve pertussis vaccines.
format Articulo
Articulo
author Bottero, Daniela
Gaillard, María Emilia
Hozbor, Daniela Flavia
author_facet Bottero, Daniela
Gaillard, María Emilia
Hozbor, Daniela Flavia
author_sort Bottero, Daniela
title Global population structure and evolution of Bordetella pertussis and their relationship with vaccination
title_short Global population structure and evolution of Bordetella pertussis and their relationship with vaccination
title_full Global population structure and evolution of Bordetella pertussis and their relationship with vaccination
title_fullStr Global population structure and evolution of Bordetella pertussis and their relationship with vaccination
title_full_unstemmed Global population structure and evolution of Bordetella pertussis and their relationship with vaccination
title_sort global population structure and evolution of bordetella pertussis and their relationship with vaccination
publishDate 2014
url http://sedici.unlp.edu.ar/handle/10915/84867
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