Autocrine stimulation of cardiac Na+-Ca2+ exchanger currents by endogenous endothelin released by angiotensin II

The goal of the present study was to evaluate the effects of Ang II on the current produced by the Na<SUP>+</SUP>-Ca<SUP>2+</SUP> exchanger (I<SUB>NCX</SUB>) working in the reverse mode and the possible autocrine role played by the release of endothelin (ET) in th...

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Detalles Bibliográficos
Autores principales: Aiello, Ernesto Alejandro, Villa Abrille, María Celeste, Cingolani, Horacio Eugenio
Formato: Articulo Comunicacion
Lenguaje:Inglés
Publicado: 2002
Materias:
Ciencias Médicas
Angiotensin II
Cardiac myocytes
Endothelin
Sodium-calcium exchanger
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/84668
Aporte de:
SEDICI (UNLP) de Universidad Nacional de La Plata
id I19-R120-10915-84668
record_format dspace
institution Universidad Nacional de La Plata
institution_str I-19
repository_str R-120
collection SEDICI (UNLP)
language Inglés
topic Ciencias Médicas
Angiotensin II
Cardiac myocytes
Endothelin
Sodium-calcium exchanger
spellingShingle Ciencias Médicas
Angiotensin II
Cardiac myocytes
Endothelin
Sodium-calcium exchanger
Aiello, Ernesto Alejandro
Villa Abrille, María Celeste
Cingolani, Horacio Eugenio
Autocrine stimulation of cardiac Na+-Ca2+ exchanger currents by endogenous endothelin released by angiotensin II
topic_facet Ciencias Médicas
Angiotensin II
Cardiac myocytes
Endothelin
Sodium-calcium exchanger
description The goal of the present study was to evaluate the effects of Ang II on the current produced by the Na<SUP>+</SUP>-Ca<SUP>2+</SUP> exchanger (I<SUB>NCX</SUB>) working in the reverse mode and the possible autocrine role played by the release of endothelin (ET) in these actions. I<SUB>NCX</SUB> was studied in isolation in cat cardiac myocytes. Angiotensin II (Ang II) (100 nmol/L) increased I<SUB>NCX</SUB> at potentials higher than 0 mV (at +60 mV: 2.07±0.22 pA/pF in control versus 2.73±0.22 pA/pF in Ang II, n = 9; P < 0.05). The increase in I<SUB>NCX</SUB> induced by Ang II was prevented by the treatment of the cells with the unspecific blocker of the ET receptors, TAK 044 (1 μmol/L) (at +60 mV: 2.15±0.27 pA/pF in control versus 2.01±0.26 pA/pF in Ang II, n=5, NS). These results show, for the first time, that the effect of Ang II on I<SUB>NCX</SUB> is the result of the autocrine actions of ET released by the octapeptide.
format Articulo
Comunicacion
author Aiello, Ernesto Alejandro
Villa Abrille, María Celeste
Cingolani, Horacio Eugenio
author_facet Aiello, Ernesto Alejandro
Villa Abrille, María Celeste
Cingolani, Horacio Eugenio
author_sort Aiello, Ernesto Alejandro
title Autocrine stimulation of cardiac Na+-Ca2+ exchanger currents by endogenous endothelin released by angiotensin II
title_short Autocrine stimulation of cardiac Na+-Ca2+ exchanger currents by endogenous endothelin released by angiotensin II
title_full Autocrine stimulation of cardiac Na+-Ca2+ exchanger currents by endogenous endothelin released by angiotensin II
title_fullStr Autocrine stimulation of cardiac Na+-Ca2+ exchanger currents by endogenous endothelin released by angiotensin II
title_full_unstemmed Autocrine stimulation of cardiac Na+-Ca2+ exchanger currents by endogenous endothelin released by angiotensin II
title_sort autocrine stimulation of cardiac na+-ca2+ exchanger currents by endogenous endothelin released by angiotensin ii
publishDate 2002
url http://sedici.unlp.edu.ar/handle/10915/84668
work_keys_str_mv AT aielloernestoalejandro autocrinestimulationofcardiacnaca2exchangercurrentsbyendogenousendothelinreleasedbyangiotensinii
AT villaabrillemariaceleste autocrinestimulationofcardiacnaca2exchangercurrentsbyendogenousendothelinreleasedbyangiotensinii
AT cingolanihoracioeugenio autocrinestimulationofcardiacnaca2exchangercurrentsbyendogenousendothelinreleasedbyangiotensinii
bdutipo_str Repositorios
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