Invasive breast cancer in Argentine women: Association between risk and prognostic factors with antigens of a peptidic and carbohydrate nature

Objective: In breast cancer, several tumor markers have been identified. The marker most extensively associated with breast cancer is MUC1. The objective of the study was to analyze prognostic and risk factors in relation to tumor markers in order to clarify breast cancer biology. A total of 349 pri...

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Autores principales: Demichelis, Sandra O., Isla Larrain, Marina Teresita, Cermignani, Luciano, Alberdi, Cecilio G., Segal-Eiras, Amada, Croce, María Virginia
Formato: Articulo
Lenguaje:Inglés
Publicado: 2011
Materias:
Ciencias Médicas
Antigenic expression
Argentine women
Breast cancer
Prognostic factors
Risk factors
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/84666
Aporte de:
SEDICI (UNLP) de Universidad Nacional de La Plata
id I19-R120-10915-84666
record_format dspace
institution Universidad Nacional de La Plata
institution_str I-19
repository_str R-120
collection SEDICI (UNLP)
language Inglés
topic Ciencias Médicas
Antigenic expression
Argentine women
Breast cancer
Prognostic factors
Risk factors
spellingShingle Ciencias Médicas
Antigenic expression
Argentine women
Breast cancer
Prognostic factors
Risk factors
Demichelis, Sandra O.
Isla Larrain, Marina Teresita
Cermignani, Luciano
Alberdi, Cecilio G.
Segal-Eiras, Amada
Croce, María Virginia
Invasive breast cancer in Argentine women: Association between risk and prognostic factors with antigens of a peptidic and carbohydrate nature
topic_facet Ciencias Médicas
Antigenic expression
Argentine women
Breast cancer
Prognostic factors
Risk factors
description Objective: In breast cancer, several tumor markers have been identified. The marker most extensively associated with breast cancer is MUC1. The objective of the study was to analyze prognostic and risk factors in relation to tumor markers in order to clarify breast cancer biology. A total of 349 primary tumor samples and lymph nodes from breast cancer patients were studied. Risk and prognostic factors were considered. An immunohistochemical approach was applied and an extensive statistical analysis was performed, including frequency analysis and analysis of variance. Correlation among variables was performed with principal component analysis. Results: All the antigens showed an increased expression according to tumor size increment; moreover, sialyl Lewis x expression showed a significant increase in relation to disease stage, whereas Tn and TF presented a positive tendency. Vascular invasion was related to sialyl Lewis x expression and number of metastatic lymph nodes. Taking into account risk factors, when a patient had at least one child, Lewis antigens diminished their expression. In relation to breastfeeding, sialyl Lewis x expression diminished, although its apical expression increased. Conclusion: Associations between MUC1 and carbohydrate antigens and risk and prognostic factors show the complexity of the cellular biological behavior that these antigens modulate in breast cancer.
format Articulo
Articulo
author Demichelis, Sandra O.
Isla Larrain, Marina Teresita
Cermignani, Luciano
Alberdi, Cecilio G.
Segal-Eiras, Amada
Croce, María Virginia
author_facet Demichelis, Sandra O.
Isla Larrain, Marina Teresita
Cermignani, Luciano
Alberdi, Cecilio G.
Segal-Eiras, Amada
Croce, María Virginia
author_sort Demichelis, Sandra O.
title Invasive breast cancer in Argentine women: Association between risk and prognostic factors with antigens of a peptidic and carbohydrate nature
title_short Invasive breast cancer in Argentine women: Association between risk and prognostic factors with antigens of a peptidic and carbohydrate nature
title_full Invasive breast cancer in Argentine women: Association between risk and prognostic factors with antigens of a peptidic and carbohydrate nature
title_fullStr Invasive breast cancer in Argentine women: Association between risk and prognostic factors with antigens of a peptidic and carbohydrate nature
title_full_unstemmed Invasive breast cancer in Argentine women: Association between risk and prognostic factors with antigens of a peptidic and carbohydrate nature
title_sort invasive breast cancer in argentine women: association between risk and prognostic factors with antigens of a peptidic and carbohydrate nature
publishDate 2011
url http://sedici.unlp.edu.ar/handle/10915/84666
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