Regression of cardiomyocyte hypertrophy in SHR following chronic inhibition of the Na+/H+ exchanger

Objective: Experiments were performed to examine the effect of chronic inhibition of the Na<SUP>+</SUP>/H<SUP>+</SUP> exchanger isoform-1 (NHE-1) on cardiac hypertrophy of spontaneously hypertensive rats (SHR). Methods: SHR were orally treated during 1 month with two differen...

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Autores principales: Camilión de Hurtado, María Cristina, Portiansky, Enrique Leo, Pérez, Néstor Gustavo, Rebolledo, Oscar Remigio, Cingolani, Horacio Eugenio
Formato: Articulo
Lenguaje:Inglés
Publicado: 2002
Materias:
Ciencias Médicas
Fibrosis
Hypertension
Hypertrophy
Ion exchangers
Na/H exchanger
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/84662
Aporte de:
SEDICI (UNLP) de Universidad Nacional de La Plata
id I19-R120-10915-84662
record_format dspace
institution Universidad Nacional de La Plata
institution_str I-19
repository_str R-120
collection SEDICI (UNLP)
language Inglés
topic Ciencias Médicas
Fibrosis
Hypertension
Hypertrophy
Ion exchangers
Na/H exchanger
spellingShingle Ciencias Médicas
Fibrosis
Hypertension
Hypertrophy
Ion exchangers
Na/H exchanger
Camilión de Hurtado, María Cristina
Portiansky, Enrique Leo
Pérez, Néstor Gustavo
Rebolledo, Oscar Remigio
Cingolani, Horacio Eugenio
Regression of cardiomyocyte hypertrophy in SHR following chronic inhibition of the Na+/H+ exchanger
topic_facet Ciencias Médicas
Fibrosis
Hypertension
Hypertrophy
Ion exchangers
Na/H exchanger
description Objective: Experiments were performed to examine the effect of chronic inhibition of the Na<SUP>+</SUP>/H<SUP>+</SUP> exchanger isoform-1 (NHE-1) on cardiac hypertrophy of spontaneously hypertensive rats (SHR). Methods: SHR were orally treated during 1 month with two different doses (0.3 and 3.0 mg/kg/day) of the NHE-1 inhibitor, cariporide, or nifedipine (10.0 mg/kg/day). Results: The two doses of cariporide did not differ in their effects after 1 month of treatment, since both induced a slight decrease in systolic blood pressure (SBP) of ∼6 mmHg and regression of the heart weight to body weight ratio (mg/g) from 3.28±0.05 to 3.04±0.05 (0.3 mg) and 2.99±0.10 (3.0 mg, P<0.05). Nifedipine, given for the same period, produced similar reduction in the hypertrophy index (3.03±0.05), but with a much greater decrease in arterial pressure (35.6±7.4 mmHg). Chronic treatment with cariporide induced a complete regression of the augmented cross sectional area of left ventricular myocytes without significant changes in collagen content, serum procollagen 1 propeptide levels or myocardial distensibility. Conclusions: NHE inhibition represents a novel approach to induce regression of pathological hypertrophy of the heart. The finding can be rationalized mechanistically by previous in vitro studies suggesting a role of the NHE in the development of myocardial hypertrophy.
format Articulo
Articulo
author Camilión de Hurtado, María Cristina
Portiansky, Enrique Leo
Pérez, Néstor Gustavo
Rebolledo, Oscar Remigio
Cingolani, Horacio Eugenio
author_facet Camilión de Hurtado, María Cristina
Portiansky, Enrique Leo
Pérez, Néstor Gustavo
Rebolledo, Oscar Remigio
Cingolani, Horacio Eugenio
author_sort Camilión de Hurtado, María Cristina
title Regression of cardiomyocyte hypertrophy in SHR following chronic inhibition of the Na+/H+ exchanger
title_short Regression of cardiomyocyte hypertrophy in SHR following chronic inhibition of the Na+/H+ exchanger
title_full Regression of cardiomyocyte hypertrophy in SHR following chronic inhibition of the Na+/H+ exchanger
title_fullStr Regression of cardiomyocyte hypertrophy in SHR following chronic inhibition of the Na+/H+ exchanger
title_full_unstemmed Regression of cardiomyocyte hypertrophy in SHR following chronic inhibition of the Na+/H+ exchanger
title_sort regression of cardiomyocyte hypertrophy in shr following chronic inhibition of the na+/h+ exchanger
publishDate 2002
url http://sedici.unlp.edu.ar/handle/10915/84662
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