Mass spectrometry of 1,2,5-oxadiazole N-oxide derivatives. Use of deuterated analogues in fragmentation pattern studies

This paper reported on the study of fragmentation pattern in mass spectrometry of 1,2,5-oxadiazole N-oxide derivatives involving deuterium-labeled analogues to identify some critical fragmentations. A neutral CH<SUB>2</SUB>O loss from 3-hydroxymethyl-N<SUB>2</SUB>-oxide-4-phe...

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Autores principales: Cerecetto, Hugo, González, Mercedes, Seoane, Gustavo, Stanko, Carola, Piro, Oscar Enrique, Castellano, Eduardo Ernesto
Formato: Articulo
Lenguaje:Inglés
Publicado: 2004
Materias:
Ciencias Exactas
1,2,5-oxadiazole N-oxide
D-labeled furoxan
EI/MS
Mass fragmentation
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/84487
Aporte de:
SEDICI (UNLP) de Universidad Nacional de La Plata
id I19-R120-10915-84487
record_format dspace
institution Universidad Nacional de La Plata
institution_str I-19
repository_str R-120
collection SEDICI (UNLP)
language Inglés
topic Ciencias Exactas
1,2,5-oxadiazole N-oxide
D-labeled furoxan
EI/MS
Mass fragmentation
spellingShingle Ciencias Exactas
1,2,5-oxadiazole N-oxide
D-labeled furoxan
EI/MS
Mass fragmentation
Cerecetto, Hugo
González, Mercedes
Seoane, Gustavo
Stanko, Carola
Piro, Oscar Enrique
Castellano, Eduardo Ernesto
Mass spectrometry of 1,2,5-oxadiazole N-oxide derivatives. Use of deuterated analogues in fragmentation pattern studies
topic_facet Ciencias Exactas
1,2,5-oxadiazole N-oxide
D-labeled furoxan
EI/MS
Mass fragmentation
description This paper reported on the study of fragmentation pattern in mass spectrometry of 1,2,5-oxadiazole N-oxide derivatives involving deuterium-labeled analogues to identify some critical fragmentations. A neutral CH<SUB>2</SUB>O loss from 3-hydroxymethyl-N<SUB>2</SUB>-oxide-4-phenyl-1,2,5-oxadiazole was confirmed with the corresponding mono-deuterated analogue. An OH loss, involving the oxygen of N-oxide, via β-H and δ-H rearrangement, was clearly revealed from 3-(4-methylpiperazine-1-ylmethyl)-N<SUB>2</SUB>-oxide-4-phenyl-1, 2,5-oxadiazole using the adequate tetra-deuterated analogue. N-oxide isomer and deoxygenated analogues were also used to confirm the participation of the oxide moiety in the fragmentation process.
format Articulo
Articulo
author Cerecetto, Hugo
González, Mercedes
Seoane, Gustavo
Stanko, Carola
Piro, Oscar Enrique
Castellano, Eduardo Ernesto
author_facet Cerecetto, Hugo
González, Mercedes
Seoane, Gustavo
Stanko, Carola
Piro, Oscar Enrique
Castellano, Eduardo Ernesto
author_sort Cerecetto, Hugo
title Mass spectrometry of 1,2,5-oxadiazole N-oxide derivatives. Use of deuterated analogues in fragmentation pattern studies
title_short Mass spectrometry of 1,2,5-oxadiazole N-oxide derivatives. Use of deuterated analogues in fragmentation pattern studies
title_full Mass spectrometry of 1,2,5-oxadiazole N-oxide derivatives. Use of deuterated analogues in fragmentation pattern studies
title_fullStr Mass spectrometry of 1,2,5-oxadiazole N-oxide derivatives. Use of deuterated analogues in fragmentation pattern studies
title_full_unstemmed Mass spectrometry of 1,2,5-oxadiazole N-oxide derivatives. Use of deuterated analogues in fragmentation pattern studies
title_sort mass spectrometry of 1,2,5-oxadiazole n-oxide derivatives. use of deuterated analogues in fragmentation pattern studies
publishDate 2004
url http://sedici.unlp.edu.ar/handle/10915/84487
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