Outbreak of swine influenza in Argentina reveals a non-contemporary human H3N2 virus highly transmissible among pigs

Sporadic outbreaks of human H3N2 influenza A virus (IAV) infections in swine populations have been reported in Asia, Europe and North America since 1970. In South America, serological surveys in pigs indicate that IAVs of the H3 and H1 subtypes are currently in circulation; however, neither virus is...

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Detalles Bibliográficos
Autores principales: Cappuccio, Javier A., Pena, Lindomar, Dibárbora, Marina, Rimondi, Agustina, Piñeyro Piñeiro, Pablo Enrique, Insarralde, Lucas, Quiroga, María Alejandra, Machuca, Mariana Alejandra, Craig, Maria I., Olivera, Valeria, Chockalingam, Ashok, Perfumo, Carlos Juan, Perez, Daniel R., Pereda, Ariel
Formato: Articulo
Lenguaje:Inglés
Publicado: 2011
Materias:
Biología
Influenzavirus A
pigs
virus H3N2 IAV
humans
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/84437
Aporte de:
SEDICI (UNLP) de Universidad Nacional de La Plata
id I19-R120-10915-84437
record_format dspace
institution Universidad Nacional de La Plata
institution_str I-19
repository_str R-120
collection SEDICI (UNLP)
language Inglés
topic Biología
Influenzavirus A
pigs
virus H3N2 IAV
humans
spellingShingle Biología
Influenzavirus A
pigs
virus H3N2 IAV
humans
Cappuccio, Javier A.
Pena, Lindomar
Dibárbora, Marina
Rimondi, Agustina
Piñeyro Piñeiro, Pablo Enrique
Insarralde, Lucas
Quiroga, María Alejandra
Machuca, Mariana Alejandra
Craig, Maria I.
Olivera, Valeria
Chockalingam, Ashok
Perfumo, Carlos Juan
Perez, Daniel R.
Pereda, Ariel
Outbreak of swine influenza in Argentina reveals a non-contemporary human H3N2 virus highly transmissible among pigs
topic_facet Biología
Influenzavirus A
pigs
virus H3N2 IAV
humans
description Sporadic outbreaks of human H3N2 influenza A virus (IAV) infections in swine populations have been reported in Asia, Europe and North America since 1970. In South America, serological surveys in pigs indicate that IAVs of the H3 and H1 subtypes are currently in circulation; however, neither virus isolation nor characterization has been reported. In November 2008, an outbreak of respiratory disease in pigs consistent with swine influenza virus (SIV) infection was detected in Argentina. The current study describes the clinical epidemiology, pathology, and molecular and biological characteristics of the virus. Phylogenetic analysis revealed that the virus isolate shared nucleotide identities of 96-98% with H3N2 IAVs that circulated in humans from 2000 to 2003. Antigenically, sera from experimentally inoculated animals cross-reacted mainly with noncontemporary human-origin H3N2 influenza viruses. In an experimental infection in a commercial swine breed, the virus was of low virulence but was transmitted efficiently to contact pigs and caused severe disease when an infected animal acquired a secondary bacterial infection. This is the first report of a wholly human H3N2 IAV associated with clinical disease in pigs in South America. These studies highlight the importance of two-way transmission of IAVs and SIVs between pigs and humans, and call for enhanced influenza surveillance in the pig population worldwide.
format Articulo
Articulo
author Cappuccio, Javier A.
Pena, Lindomar
Dibárbora, Marina
Rimondi, Agustina
Piñeyro Piñeiro, Pablo Enrique
Insarralde, Lucas
Quiroga, María Alejandra
Machuca, Mariana Alejandra
Craig, Maria I.
Olivera, Valeria
Chockalingam, Ashok
Perfumo, Carlos Juan
Perez, Daniel R.
Pereda, Ariel
author_facet Cappuccio, Javier A.
Pena, Lindomar
Dibárbora, Marina
Rimondi, Agustina
Piñeyro Piñeiro, Pablo Enrique
Insarralde, Lucas
Quiroga, María Alejandra
Machuca, Mariana Alejandra
Craig, Maria I.
Olivera, Valeria
Chockalingam, Ashok
Perfumo, Carlos Juan
Perez, Daniel R.
Pereda, Ariel
author_sort Cappuccio, Javier A.
title Outbreak of swine influenza in Argentina reveals a non-contemporary human H3N2 virus highly transmissible among pigs
title_short Outbreak of swine influenza in Argentina reveals a non-contemporary human H3N2 virus highly transmissible among pigs
title_full Outbreak of swine influenza in Argentina reveals a non-contemporary human H3N2 virus highly transmissible among pigs
title_fullStr Outbreak of swine influenza in Argentina reveals a non-contemporary human H3N2 virus highly transmissible among pigs
title_full_unstemmed Outbreak of swine influenza in Argentina reveals a non-contemporary human H3N2 virus highly transmissible among pigs
title_sort outbreak of swine influenza in argentina reveals a non-contemporary human h3n2 virus highly transmissible among pigs
publishDate 2011
url http://sedici.unlp.edu.ar/handle/10915/84437
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