Simultaneous quantification of 6,7-di-hydroxyligustilide and gastrodin in rat plasma by LC-MS: application to pharmacokinetic study of tianshu capsule

A LC-MS method was developed and validated for simultaneous determination of 6, 7-di-hydroxyligustilide and gastrodin in rat plasma, and which was subsequently applied in the pharmacokinetic analysis of an administration of a Chinese herbal extract containing Chuanxiong Rhizoma and Gastrodia Elata R...

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Autores principales: Bi, Kaishun, Yan, Baoqing, Huo, Yanshuang, Chen, Xaohui, Sun, Linxin, Zhang, Huifen
Formato: Articulo
Lenguaje:Inglés
Publicado: 2012
Materias:
Farmacia
Espectrometría de Masas
Cromatografía Liquida
Farmacocinética
Ligusticum
Gastrodia
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/8437
http://www.latamjpharm.org/resumenes/31/1/LAJOP_31_1_1_17.pdf
Aporte de:
SEDICI (UNLP) de Universidad Nacional de La Plata
id I19-R120-10915-8437
record_format dspace
institution Universidad Nacional de La Plata
institution_str I-19
repository_str R-120
collection SEDICI (UNLP)
language Inglés
topic Farmacia
Espectrometría de Masas
Cromatografía Liquida
Farmacocinética
Ligusticum
Gastrodia
spellingShingle Farmacia
Espectrometría de Masas
Cromatografía Liquida
Farmacocinética
Ligusticum
Gastrodia
Bi, Kaishun
Yan, Baoqing
Huo, Yanshuang
Chen, Xaohui
Sun, Linxin
Zhang, Huifen
Simultaneous quantification of 6,7-di-hydroxyligustilide and gastrodin in rat plasma by LC-MS: application to pharmacokinetic study of tianshu capsule
topic_facet Farmacia
Espectrometría de Masas
Cromatografía Liquida
Farmacocinética
Ligusticum
Gastrodia
description A LC-MS method was developed and validated for simultaneous determination of 6, 7-di-hydroxyligustilide and gastrodin in rat plasma, and which was subsequently applied in the pharmacokinetic analysis of an administration of a Chinese herbal extract containing Chuanxiong Rhizoma and Gastrodia Elata Rhizome, i.e. TianShu capsule against migraine. The analytes were separated on a Kromasil C18 column with a gradient elution program and detected without interference in the selected ion monitoring mode with positive electrospray ionization. The linear range was 0.010-10.0 μg/mL for 6,7-di-hydroxyligustilide and 0.025-25.0 μg/mL for gastrodin with the limit of quantitation of 0.01 and 0.025 μg/mL, respectively. The intra-day and inter-day precisions for the entire validation were less than14.7 % of RSD. The pharmacokinetic parameters indicated that 6, 7-di-hydroxyligustilide and gastrodin are absorbed rapidly and reached a maximum concentration within one hour, which was consistent with the clinical requirements for the rapid relieving the symptoms of migraine.
format Articulo
Articulo
author Bi, Kaishun
Yan, Baoqing
Huo, Yanshuang
Chen, Xaohui
Sun, Linxin
Zhang, Huifen
author_facet Bi, Kaishun
Yan, Baoqing
Huo, Yanshuang
Chen, Xaohui
Sun, Linxin
Zhang, Huifen
author_sort Bi, Kaishun
title Simultaneous quantification of 6,7-di-hydroxyligustilide and gastrodin in rat plasma by LC-MS: application to pharmacokinetic study of tianshu capsule
title_short Simultaneous quantification of 6,7-di-hydroxyligustilide and gastrodin in rat plasma by LC-MS: application to pharmacokinetic study of tianshu capsule
title_full Simultaneous quantification of 6,7-di-hydroxyligustilide and gastrodin in rat plasma by LC-MS: application to pharmacokinetic study of tianshu capsule
title_fullStr Simultaneous quantification of 6,7-di-hydroxyligustilide and gastrodin in rat plasma by LC-MS: application to pharmacokinetic study of tianshu capsule
title_full_unstemmed Simultaneous quantification of 6,7-di-hydroxyligustilide and gastrodin in rat plasma by LC-MS: application to pharmacokinetic study of tianshu capsule
title_sort simultaneous quantification of 6,7-di-hydroxyligustilide and gastrodin in rat plasma by lc-ms: application to pharmacokinetic study of tianshu capsule
publishDate 2012
url http://sedici.unlp.edu.ar/handle/10915/8437
http://www.latamjpharm.org/resumenes/31/1/LAJOP_31_1_1_17.pdf
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