Validation of a UV spectrophotometric method for determining trans-dehydrocrotonin in inclusion complexes with hydroxypropyl-β-cyclodextrin

Trans-dehydrocrotonin (t-DCTN) is a 19-nor-clerodan diterpen with several important pharmacological properties, including hypoglycemic and antitumor activity. However the low water solubility and hepatotoxicity of t-DCTN limit its use in therapeutic applications. Drug inclusion complexes with cyclod...

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Detalles Bibliográficos
Autores principales:	Santos Magalhães, Nereide S., Maciel, Maria A. M., Lira, Mariane C. B., Morais, Waldenice A., Lapenda, Taciana L.S.
Formato:	Articulo
Lenguaje:	Inglés
Publicado:	2012
Materias:	Farmacia beta-Ciclodextrinas hydroxypropyl-β-cyclodextrin; inclusion complex; trans-dehydrocrotonin; UV spectrophotometry; validation Diterpenos de Clerodano Espectrometría
Acceso en línea:	http://sedici.unlp.edu.ar/handle/10915/8435 http://www.latamjpharm.org/resumenes/31/1/LAJOP_31_1_1_15.pdf
Aporte de:	SEDICI (UNLP) de Universidad Nacional de La Plata

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