Phytochemical profile and anti-Inflammatory effect of the orchid <i>Catasetum macroglossum</i>

The pseudobulbs of Catasetum macroglossum (Orchidaceae) are popularly used as topical anti-inflammatory and antirheumatic in the forests and medium lands of Ecuador, but they were never studied. We evaluated whether the decoction of C. macroglossum has antiinflammatory effect and which is its phytoc...

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Autores principales: Consolini, Alicia E., Spegazzini, Etile Dolores, Debenedetti, Silvia Laura, Rosella, María Adelaida, Colareda, Germán A., Ramos, Pablo
Formato: Articulo
Lenguaje:Inglés
Publicado: 2012
Materias:
Farmacia
Fenantrenos
Catasetum macroglossum; HPLC-DAD; TLC
Cromatografía Líquida de Alta Presión
Estilbenos
Manosa
Glucosa
Carragenina
Agentes Antiinflamatorios
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/8430
http://www.latamjpharm.org/resumenes/31/1/LAJOP_31_1_1_10.pdf
Aporte de:
SEDICI (UNLP) de Universidad Nacional de La Plata
id I19-R120-10915-8430
record_format dspace
institution Universidad Nacional de La Plata
institution_str I-19
repository_str R-120
collection SEDICI (UNLP)
language Inglés
topic Farmacia
Fenantrenos
Catasetum macroglossum; HPLC-DAD; TLC
Cromatografía Líquida de Alta Presión
Estilbenos
Manosa
Glucosa
Carragenina
Agentes Antiinflamatorios
spellingShingle Farmacia
Fenantrenos
Catasetum macroglossum; HPLC-DAD; TLC
Cromatografía Líquida de Alta Presión
Estilbenos
Manosa
Glucosa
Carragenina
Agentes Antiinflamatorios
Consolini, Alicia E.
Spegazzini, Etile Dolores
Debenedetti, Silvia Laura
Rosella, María Adelaida
Colareda, Germán A.
Ramos, Pablo
Phytochemical profile and anti-Inflammatory effect of the orchid <i>Catasetum macroglossum</i>
topic_facet Farmacia
Fenantrenos
Catasetum macroglossum; HPLC-DAD; TLC
Cromatografía Líquida de Alta Presión
Estilbenos
Manosa
Glucosa
Carragenina
Agentes Antiinflamatorios
description The pseudobulbs of Catasetum macroglossum (Orchidaceae) are popularly used as topical anti-inflammatory and antirheumatic in the forests and medium lands of Ecuador, but they were never studied. We evaluated whether the decoction of C. macroglossum has antiinflammatory effect and which is its phytochemical profile. The effect of 30 and 90 mg lyophilized/kg via i.p. was studied on the carrageenaninduced edema in the paw rat, in comparison with saline and indomethacin. The paw edema was inhibited in about 60 to 80 % after 1 to 3 h of carrageenan injection. The phytochemical profile was done by chemical tests to evaluate the presence of reducing sugars and flavonoids, and TLC of the aqueous extract and the hydrolyzed one. There were detected reductive substances after the acidic hydrolysis, and two spots with the features and Rf of the standard glucose and mannose. Some peaks in the HPLC-DAD chromatogram showed absorption at 225 and 280 nm in agreement with dihydro derivatives of phenantrene and stilbene in traces amount. The antiinflammatory kinetic of C. macroglossum suggests inhibition on prostaglandins. This work validates the popular use of C. macroglossum, which could be due to the presence of a glucomannan and traces of phenantrene and stilbene, as in other species of Catasetum.
format Articulo
Articulo
author Consolini, Alicia E.
Spegazzini, Etile Dolores
Debenedetti, Silvia Laura
Rosella, María Adelaida
Colareda, Germán A.
Ramos, Pablo
author_facet Consolini, Alicia E.
Spegazzini, Etile Dolores
Debenedetti, Silvia Laura
Rosella, María Adelaida
Colareda, Germán A.
Ramos, Pablo
author_sort Consolini, Alicia E.
title Phytochemical profile and anti-Inflammatory effect of the orchid <i>Catasetum macroglossum</i>
title_short Phytochemical profile and anti-Inflammatory effect of the orchid <i>Catasetum macroglossum</i>
title_full Phytochemical profile and anti-Inflammatory effect of the orchid <i>Catasetum macroglossum</i>
title_fullStr Phytochemical profile and anti-Inflammatory effect of the orchid <i>Catasetum macroglossum</i>
title_full_unstemmed Phytochemical profile and anti-Inflammatory effect of the orchid <i>Catasetum macroglossum</i>
title_sort phytochemical profile and anti-inflammatory effect of the orchid <i>catasetum macroglossum</i>
publishDate 2012
url http://sedici.unlp.edu.ar/handle/10915/8430
http://www.latamjpharm.org/resumenes/31/1/LAJOP_31_1_1_10.pdf
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