In vitro trypanocidal activity of nitroimidazole derivatives
Chagas' disease, caused by the protozoan parasite Trypanosoma cruzi, affects 9-12 million of people in Latin America and it is an important cause of heart disease. Although transmission has been reduced, an effective therapy for the infected population is lacking. New isomers nitroimidazole der...
Guardado en:
| Autores principales: | , , , , , |
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| Formato: | Articulo |
| Lenguaje: | Inglés |
| Publicado: |
2012
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| Materias: | |
| Acceso en línea: | http://sedici.unlp.edu.ar/handle/10915/8429 http://www.latamjpharm.org/resumenes/31/1/LAJOP_31_1_1_9.pdf |
| Aporte de: |
| id |
I19-R120-10915-8429 |
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| record_format |
dspace |
| institution |
Universidad Nacional de La Plata |
| institution_str |
I-19 |
| repository_str |
R-120 |
| collection |
SEDICI (UNLP) |
| language |
Inglés |
| topic |
Farmacia Trypanosoma cruzi Nitroimidazoles Enfermedad de Chagas |
| spellingShingle |
Farmacia Trypanosoma cruzi Nitroimidazoles Enfermedad de Chagas Ramos Ligonio, Ángel López Monteon, Aracely Carrera Huerta, Francisco García Gálvez, Ana M. Márquez López , Elizabeth Sánchez Pavón, Esmeralda In vitro trypanocidal activity of nitroimidazole derivatives |
| topic_facet |
Farmacia Trypanosoma cruzi Nitroimidazoles Enfermedad de Chagas |
| description |
Chagas' disease, caused by the protozoan parasite Trypanosoma cruzi, affects 9-12 million of people in Latin America and it is an important cause of heart disease. Although transmission has been reduced, an effective therapy for the infected population is lacking. New isomers nitroimidazole derivatives [4(5)-bromo-1-phenacyl-5(4)-nitroimidazoles] were developed and their antichagasic properties were studied. Five compounds (with different substituents in their aromatic ring) displayed remarkable in vitro activities against T. cruzi. The results demonstrated that 4(5)-bromo-1-(4-methoxiphenacyl)-2-methyl-5(4)- nitroimidazole, 4(5)-bromo-1-(4-chlorophenacyl)-2-methyl-5(4)-nitroimidazole, and 4(5)-bromo-1-(4- cianophenacyl)-2-methyl-5(4)-nitroimidazole have IC50 values of of 3.95, 2.3, and 1.15 μg/mL, respectively, and show acceptable values of cytotoxicity, at concentrations below 5 μg/mL. Our results indicate that mixtures of isomers are a potent inhibitor of T. cruzi growth. The present evidence shows very promising results of new isomers, which emerge as strong candidates for further tests as anti-T. cruzi agents. |
| format |
Articulo Articulo |
| author |
Ramos Ligonio, Ángel López Monteon, Aracely Carrera Huerta, Francisco García Gálvez, Ana M. Márquez López , Elizabeth Sánchez Pavón, Esmeralda |
| author_facet |
Ramos Ligonio, Ángel López Monteon, Aracely Carrera Huerta, Francisco García Gálvez, Ana M. Márquez López , Elizabeth Sánchez Pavón, Esmeralda |
| author_sort |
Ramos Ligonio, Ángel |
| title |
In vitro trypanocidal activity of nitroimidazole derivatives |
| title_short |
In vitro trypanocidal activity of nitroimidazole derivatives |
| title_full |
In vitro trypanocidal activity of nitroimidazole derivatives |
| title_fullStr |
In vitro trypanocidal activity of nitroimidazole derivatives |
| title_full_unstemmed |
In vitro trypanocidal activity of nitroimidazole derivatives |
| title_sort |
in vitro trypanocidal activity of nitroimidazole derivatives |
| publishDate |
2012 |
| url |
http://sedici.unlp.edu.ar/handle/10915/8429 http://www.latamjpharm.org/resumenes/31/1/LAJOP_31_1_1_9.pdf |
| work_keys_str_mv |
AT ramosligonioangel invitrotrypanocidalactivityofnitroimidazolederivatives AT lopezmonteonaracely invitrotrypanocidalactivityofnitroimidazolederivatives AT carrerahuertafrancisco invitrotrypanocidalactivityofnitroimidazolederivatives AT garciagalvezanam invitrotrypanocidalactivityofnitroimidazolederivatives AT marquezlopezelizabeth invitrotrypanocidalactivityofnitroimidazolederivatives AT sanchezpavonesmeralda invitrotrypanocidalactivityofnitroimidazolederivatives |
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Repositorios |
| _version_ |
1764820488568176641 |