Growth of functional cranial components in rats with intrauterine growth retardation after treatment with growth hormone

The goal of this study was to analyse the effect of growth hormone (GH) on catch-up growth of functional facial (splanchnocranial) and neurocranial components in rats with intrauterine growth retardation (IUGR). Wistar rats were divided into the following groups: control (C), sham-operated (SH), IUG...

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Autores principales: Quintero, Fabián Aníbal, Castro, Luis Eduardo, Luna, María Eugenia, Guimarey, Luis Manuel, Cesani Rossi, María Florencia, Fucini, María Cecilia, Villanueva, Myriam, Prio, Verónica, Oyhenart, Evelia Edith
Formato: Articulo
Lenguaje:Inglés
Publicado: 2012
Materias:
Ciencias Veterinarias
Crecimiento
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/84283
Aporte de:
SEDICI (UNLP) de Universidad Nacional de La Plata
id I19-R120-10915-84283
record_format dspace
institution Universidad Nacional de La Plata
institution_str I-19
repository_str R-120
collection SEDICI (UNLP)
language Inglés
topic Ciencias Veterinarias
Crecimiento
spellingShingle Ciencias Veterinarias
Crecimiento
Quintero, Fabián Aníbal
Castro, Luis Eduardo
Luna, María Eugenia
Guimarey, Luis Manuel
Cesani Rossi, María Florencia
Fucini, María Cecilia
Villanueva, Myriam
Prio, Verónica
Oyhenart, Evelia Edith
Growth of functional cranial components in rats with intrauterine growth retardation after treatment with growth hormone
topic_facet Ciencias Veterinarias
Crecimiento
description The goal of this study was to analyse the effect of growth hormone (GH) on catch-up growth of functional facial (splanchnocranial) and neurocranial components in rats with intrauterine growth retardation (IUGR). Wistar rats were divided into the following groups: control (C), sham-operated (SH), IUGR, and IUGR + GH. IUGR was surgically induced and GH was administered between 21 and 60 days of age. Radiographs were obtained at 1, 21, 42, 63, and 84 days of age in order to measure length, width, and height of neurocranium (NL, NW, and NH) and face length, width, and height (FL, FW, and FH). Analysis of variance was perfomed at 1 day of age and a principal components analysis (PCA) at 84 days of age. Neurocranial and facial volumetric indexes were calculated as NVI = 3√NL × NW × NH and FVI = 3√FL × FW × FH, respectively, and adjusted by non-linear regression analysis. On postnatal day 1, there were significant differences between SH and IUGR (P < 0.01). Also, in both genders, final neurocranial volume was similar between SH and IUGR + GH groups, while the IUGR group had the lower value (P < 0.01). Final facial volume was similar among the three groups. In both genders, facial growth rates were SH = IUGR > IUGR + GH (P < 0.01). The first axis of the PCA exhibited size effect and the second axis showed shape effect. Reductions of placental blood flow modify cranial growth. The functional neurocranial and facial components in rats with IUGR presented different recovery strategies through modular behaviour, mainly related to modifications of growth rate as response to GH administration.
format Articulo
Articulo
author Quintero, Fabián Aníbal
Castro, Luis Eduardo
Luna, María Eugenia
Guimarey, Luis Manuel
Cesani Rossi, María Florencia
Fucini, María Cecilia
Villanueva, Myriam
Prio, Verónica
Oyhenart, Evelia Edith
author_facet Quintero, Fabián Aníbal
Castro, Luis Eduardo
Luna, María Eugenia
Guimarey, Luis Manuel
Cesani Rossi, María Florencia
Fucini, María Cecilia
Villanueva, Myriam
Prio, Verónica
Oyhenart, Evelia Edith
author_sort Quintero, Fabián Aníbal
title Growth of functional cranial components in rats with intrauterine growth retardation after treatment with growth hormone
title_short Growth of functional cranial components in rats with intrauterine growth retardation after treatment with growth hormone
title_full Growth of functional cranial components in rats with intrauterine growth retardation after treatment with growth hormone
title_fullStr Growth of functional cranial components in rats with intrauterine growth retardation after treatment with growth hormone
title_full_unstemmed Growth of functional cranial components in rats with intrauterine growth retardation after treatment with growth hormone
title_sort growth of functional cranial components in rats with intrauterine growth retardation after treatment with growth hormone
publishDate 2012
url http://sedici.unlp.edu.ar/handle/10915/84283
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