Floating gellan-chitosan polyelectrolyte complex beads: effect of gelucires incorporation on encapsulation efficiency and drug release

The purpose of the present investigation is to study the effect of incorporation of gelucire 39/01 and 50/13 on encapsulation efficiency and release of water soluble drug (metronidazole, log P = 0.0) from floating gellan-chitosan polyelectrolyte complex (PEC) beads. Floating emulsion PEC beds were p...

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Detalles Bibliográficos
Autores principales:	Pandit, Jayant K., Verma, Navneet, Mishra, Arun K., Verma, Anurag, Dixit, Raghav
Formato:	Articulo
Lenguaje:	Inglés
Publicado:	2012
Materias:	Farmacia Quitosana complex coacervation; emulsion beads; floating drug delivery; gellan-chitosan beads; gelucire; polyelectrolyte complex Glicerol Metronidazol Sistemas de Liberación de Medicamentos
Acceso en línea:	http://sedici.unlp.edu.ar/handle/10915/8426 http://www.latamjpharm.org/resumenes/31/1/LAJOP_31_1_1_6.pdf
Aporte de:	SEDICI (UNLP) de Universidad Nacional de La Plata

id	I19-R120-10915-8426
record_format	dspace
institution	Universidad Nacional de La Plata
institution_str	I-19
repository_str	R-120
collection	SEDICI (UNLP)
language	Inglés
topic	Farmacia Quitosana complex coacervation; emulsion beads; floating drug delivery; gellan-chitosan beads; gelucire; polyelectrolyte complex Glicerol Metronidazol Sistemas de Liberación de Medicamentos
spellingShingle	Farmacia Quitosana complex coacervation; emulsion beads; floating drug delivery; gellan-chitosan beads; gelucire; polyelectrolyte complex Glicerol Metronidazol Sistemas de Liberación de Medicamentos Pandit, Jayant K. Verma, Navneet Mishra, Arun K. Verma, Anurag Dixit, Raghav Floating gellan-chitosan polyelectrolyte complex beads: effect of gelucires incorporation on encapsulation efficiency and drug release
topic_facet	Farmacia Quitosana complex coacervation; emulsion beads; floating drug delivery; gellan-chitosan beads; gelucire; polyelectrolyte complex Glicerol Metronidazol Sistemas de Liberación de Medicamentos
description	The purpose of the present investigation is to study the effect of incorporation of gelucire 39/01 and 50/13 on encapsulation efficiency and release of water soluble drug (metronidazole, log P = 0.0) from floating gellan-chitosan polyelectrolyte complex (PEC) beads. Floating emulsion PEC beds were prepared in one step without using any chemical crosslinker. Briefly, an emulsion of gellan gum (GG) with gelucire 39/01 and 50/13 containing CaCO<sub>3</sub> and drug was extruded dropwise into low molecular weight chitosan (LMCH) solution. Beads formed instantaneously were cured for 15 min at elevated temperature (37 °C). Prepared beads showed excellent buoyancy along with significantly improved encapsulation efficiency and sustained release of metronidazole when compared to floating gellan-chitosan PEC beads prepared in the similar manner but without gelucires. Experimental data obtained from the present investigation showed that floating emulsion PEC beads may form a potential stomach site specific drug delivery system for the delivery of highly water soluble drugs with an absorption window in the upper gastrointestinal tract.
format	Articulo Articulo
author	Pandit, Jayant K. Verma, Navneet Mishra, Arun K. Verma, Anurag Dixit, Raghav
author_facet	Pandit, Jayant K. Verma, Navneet Mishra, Arun K. Verma, Anurag Dixit, Raghav
author_sort	Pandit, Jayant K.
title	Floating gellan-chitosan polyelectrolyte complex beads: effect of gelucires incorporation on encapsulation efficiency and drug release
title_short	Floating gellan-chitosan polyelectrolyte complex beads: effect of gelucires incorporation on encapsulation efficiency and drug release
title_full	Floating gellan-chitosan polyelectrolyte complex beads: effect of gelucires incorporation on encapsulation efficiency and drug release
title_fullStr	Floating gellan-chitosan polyelectrolyte complex beads: effect of gelucires incorporation on encapsulation efficiency and drug release
title_full_unstemmed	Floating gellan-chitosan polyelectrolyte complex beads: effect of gelucires incorporation on encapsulation efficiency and drug release
title_sort	floating gellan-chitosan polyelectrolyte complex beads: effect of gelucires incorporation on encapsulation efficiency and drug release
publishDate	2012
url	http://sedici.unlp.edu.ar/handle/10915/8426 http://www.latamjpharm.org/resumenes/31/1/LAJOP_31_1_1_6.pdf
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bdutipo_str	Repositorios
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Floating gellan-chitosan polyelectrolyte complex beads: effect of gelucires incorporation on encapsulation efficiency and drug release

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