Antibacterial activity of cefoperazone metal complexes

Cefoperazone complexes with different metal ions of 1:1 metal to antibiotic stoichiometry have been prepared. The [M(cefopz)CI] complexes (M = Co, Cu and Cd) were characterized by physicochemical and spectroscopic methods. The solubility of the cefoperazone complexes in water and common organic solv...

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Autores principales: Lopez, María E., Bravo, Alina, Anacona, Juan R.
Formato: Articulo
Lenguaje:Inglés
Publicado: 2012
Materias:
Farmacia
Metales
antibiótico
Cefoperazona
Agentes Antibacterianos
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/8424
http://www.latamjpharm.org/resumenes/31/1/LAJOP_31_1_1_4.pdf
Aporte de:
SEDICI (UNLP) de Universidad Nacional de La Plata
id I19-R120-10915-8424
record_format dspace
institution Universidad Nacional de La Plata
institution_str I-19
repository_str R-120
collection SEDICI (UNLP)
language Inglés
topic Farmacia
Metales
antibiótico
Cefoperazona
Agentes Antibacterianos
spellingShingle Farmacia
Metales
antibiótico
Cefoperazona
Agentes Antibacterianos
Lopez, María E.
Bravo, Alina
Anacona, Juan R.
Antibacterial activity of cefoperazone metal complexes
topic_facet Farmacia
Metales
antibiótico
Cefoperazona
Agentes Antibacterianos
description Cefoperazone complexes with different metal ions of 1:1 metal to antibiotic stoichiometry have been prepared. The [M(cefopz)CI] complexes (M = Co, Cu and Cd) were characterized by physicochemical and spectroscopic methods. The solubility of the cefoperazone complexes in water and common organic solvents is reduced on complexation. All complexes show higher activity against Salmonella enteritidis. The Co(II) and Cd(II) complexes show better activity in the case of Pseudomonas aeruginosa and Escherichia coli, and Cu(II) and Cd(II) complexes against Shigella sonnei than cefoperazone sodium. The complexes showed to be less active than free cefoperazone against Staphylococcus aureus and Proteus mirabilis.
format Articulo
Articulo
author Lopez, María E.
Bravo, Alina
Anacona, Juan R.
author_facet Lopez, María E.
Bravo, Alina
Anacona, Juan R.
author_sort Lopez, María E.
title Antibacterial activity of cefoperazone metal complexes
title_short Antibacterial activity of cefoperazone metal complexes
title_full Antibacterial activity of cefoperazone metal complexes
title_fullStr Antibacterial activity of cefoperazone metal complexes
title_full_unstemmed Antibacterial activity of cefoperazone metal complexes
title_sort antibacterial activity of cefoperazone metal complexes
publishDate 2012
url http://sedici.unlp.edu.ar/handle/10915/8424
http://www.latamjpharm.org/resumenes/31/1/LAJOP_31_1_1_4.pdf
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AT bravoalina antibacterialactivityofcefoperazonemetalcomplexes
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bdutipo_str Repositorios
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