Antitumor and apoptosis induction effects of lupeol on U14 cervical carcinoma bearing mice

Lupeol is a naturally occurring pentacyclic triterpene that is present in a variety of plants throughout the world. Previous studies have demonstrated that it is a biologically active compound that exhibits various pharmacological properties. In this study, the antitumor activity and potential mecha...

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Autores principales: Han, Zengsheng, Li, Kun, Zhang, Xiaobo, Li, Qingwang, Wang, Peijun, Wang, Jianjie
Formato: Articulo
Lenguaje:Inglés
Publicado: 2012
Materias:
Farmacia
Carcinoma
Triterpenos Pentacíclicos
Ciclo Celular
Apoptosis
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/8422
http://www.latamjpharm.org/resumenes/31/1/LAJOP_31_1_1_2.pdf
Aporte de:
SEDICI (UNLP) de Universidad Nacional de La Plata
id I19-R120-10915-8422
record_format dspace
institution Universidad Nacional de La Plata
institution_str I-19
repository_str R-120
collection SEDICI (UNLP)
language Inglés
topic Farmacia
Carcinoma
Triterpenos Pentacíclicos
Ciclo Celular
Apoptosis
spellingShingle Farmacia
Carcinoma
Triterpenos Pentacíclicos
Ciclo Celular
Apoptosis
Han, Zengsheng
Li, Kun
Zhang, Xiaobo
Li, Qingwang
Wang, Peijun
Wang, Jianjie
Antitumor and apoptosis induction effects of lupeol on U14 cervical carcinoma bearing mice
topic_facet Farmacia
Carcinoma
Triterpenos Pentacíclicos
Ciclo Celular
Apoptosis
description Lupeol is a naturally occurring pentacyclic triterpene that is present in a variety of plants throughout the world. Previous studies have demonstrated that it is a biologically active compound that exhibits various pharmacological properties. In this study, the antitumor activity and potential mechanisms of lupeol were evaluated by investigating the effects of various dosages of lupeol on the growth of U14 tumors transplanted in mice. After lupeol was administered to cervical carcinoma bearing mice, the results demonstrated that lupeol (100 mg/kg and 200 mg/kg) effectively inhibited growth of cervical carcinoma. Compared with the control group (treated with cyclophosphamide CTX), lupeol markedly increase the number of tumor cells in G0/G1 phase. The number of apoptotic cells in the tumor also exhibited an increase in the lupeol groups and the CTX group. Meanwhile, expression of bcl-2 and c-erbB-2 was downregulated, and expression of p21, bax, caspase-8 and caspase-3 was upregulated in tumor cells. These results suggest that lupeol exhibits antitumor activity and inhibits the growth of U14 cervical carcinoma via induction of apoptosis and cell cycle arrest in mice.
format Articulo
Articulo
author Han, Zengsheng
Li, Kun
Zhang, Xiaobo
Li, Qingwang
Wang, Peijun
Wang, Jianjie
author_facet Han, Zengsheng
Li, Kun
Zhang, Xiaobo
Li, Qingwang
Wang, Peijun
Wang, Jianjie
author_sort Han, Zengsheng
title Antitumor and apoptosis induction effects of lupeol on U14 cervical carcinoma bearing mice
title_short Antitumor and apoptosis induction effects of lupeol on U14 cervical carcinoma bearing mice
title_full Antitumor and apoptosis induction effects of lupeol on U14 cervical carcinoma bearing mice
title_fullStr Antitumor and apoptosis induction effects of lupeol on U14 cervical carcinoma bearing mice
title_full_unstemmed Antitumor and apoptosis induction effects of lupeol on U14 cervical carcinoma bearing mice
title_sort antitumor and apoptosis induction effects of lupeol on u14 cervical carcinoma bearing mice
publishDate 2012
url http://sedici.unlp.edu.ar/handle/10915/8422
http://www.latamjpharm.org/resumenes/31/1/LAJOP_31_1_1_2.pdf
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AT likun antitumorandapoptosisinductioneffectsoflupeolonu14cervicalcarcinomabearingmice
AT zhangxiaobo antitumorandapoptosisinductioneffectsoflupeolonu14cervicalcarcinomabearingmice
AT liqingwang antitumorandapoptosisinductioneffectsoflupeolonu14cervicalcarcinomabearingmice
AT wangpeijun antitumorandapoptosisinductioneffectsoflupeolonu14cervicalcarcinomabearingmice
AT wangjianjie antitumorandapoptosisinductioneffectsoflupeolonu14cervicalcarcinomabearingmice
bdutipo_str Repositorios
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