Thermodynamics of sulfanilamide solubility in propylene glycol + water mixtures

The solubility of sulfanilamide (SA) in propylene glycol + water cosolvent mixtures was determined at temperatures from 293.15 to 313.15 K. The thermodynamic functions: Gibbs energy, enthalpy, and entropy of solution and mixing were obtained from these solubility data by using the van’t Hoff and Gib...

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Autores principales: Martínez, Fleming, Romdhani, Asma, Delgado, Daniel R.
Formato: Articulo
Lenguaje:Inglés
Publicado: 2011
Materias:
Farmacia
Sulfanilamidas
Solubilidad
Termodinámica
Glicol Propileno
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/8411
http://www.latamjpharm.org/resumenes/30/10/LAJOP_30_10_1_23.pdf
Aporte de:
SEDICI (UNLP) de Universidad Nacional de La Plata
id I19-R120-10915-8411
record_format dspace
institution Universidad Nacional de La Plata
institution_str I-19
repository_str R-120
collection SEDICI (UNLP)
language Inglés
topic Farmacia
Sulfanilamidas
Solubilidad
Termodinámica
Glicol Propileno
spellingShingle Farmacia
Sulfanilamidas
Solubilidad
Termodinámica
Glicol Propileno
Martínez, Fleming
Romdhani, Asma
Delgado, Daniel R.
Thermodynamics of sulfanilamide solubility in propylene glycol + water mixtures
topic_facet Farmacia
Sulfanilamidas
Solubilidad
Termodinámica
Glicol Propileno
description The solubility of sulfanilamide (SA) in propylene glycol + water cosolvent mixtures was determined at temperatures from 293.15 to 313.15 K. The thermodynamic functions: Gibbs energy, enthalpy, and entropy of solution and mixing were obtained from these solubility data by using the van’t Hoff and Gibbs equations. The solubility was maximal in propylene glycol and very low in water at all the temperatures. A non linear enthalpy–entropy relationship was observed from a plot of enthalpy vs. Gibbs energy of solution. The maximum point in plot of Δ<sub>soln</sub>H° vs. Δ<sub>soln</sub>nG° (0.20 mass fraction of propylene glycol) separates two different trends, one with negative slope from water up to 0.20 mass fraction of propylene glycol and the other one positive beyond this composition up to propylene glycol. Accordingly, the driving mechanism for SA solubility in water-rich mixtures is the entropy, probably due to water-structure loss around the drug non-polar moieties by propylene glycol, whereas, above 0.20 mass fraction of propylene glycol the driving mechanism is the enthalpy, probably due to SA solvation increase by the co-solvent molecules.
format Articulo
Articulo
author Martínez, Fleming
Romdhani, Asma
Delgado, Daniel R.
author_facet Martínez, Fleming
Romdhani, Asma
Delgado, Daniel R.
author_sort Martínez, Fleming
title Thermodynamics of sulfanilamide solubility in propylene glycol + water mixtures
title_short Thermodynamics of sulfanilamide solubility in propylene glycol + water mixtures
title_full Thermodynamics of sulfanilamide solubility in propylene glycol + water mixtures
title_fullStr Thermodynamics of sulfanilamide solubility in propylene glycol + water mixtures
title_full_unstemmed Thermodynamics of sulfanilamide solubility in propylene glycol + water mixtures
title_sort thermodynamics of sulfanilamide solubility in propylene glycol + water mixtures
publishDate 2011
url http://sedici.unlp.edu.ar/handle/10915/8411
http://www.latamjpharm.org/resumenes/30/10/LAJOP_30_10_1_23.pdf
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AT romdhaniasma thermodynamicsofsulfanilamidesolubilityinpropyleneglycolwatermixtures
AT delgadodanielr thermodynamicsofsulfanilamidesolubilityinpropyleneglycolwatermixtures
bdutipo_str Repositorios
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