Epidemiological surveillance of birth defects compatible with thalidomide embryopathy in Brazil

The thalidomide tragedy of the 1960s resulted in thousands of children being born with severe limb reduction defects (LRD), among other malformations. In Brazil, there are still babies born with thalidomide embryopathy (TE) because of leprosy prevalence, availability of thalidomide, and deficiencies...

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Detalles Bibliográficos
Autores principales: Vianna, Fernanda Sales Luiz, López Camelo, Jorge Santiago, Louguercio Leite, Júlio César, Vieira Sanseverino, Maria Teresa, Graça Dutra, Maria da, Castilla, Eduardo Enrique, Schüler Faccini, Lavínia
Formato: Articulo
Lenguaje:Inglés
Publicado: 2011
Materias:
Ciencias Médicas
Talidomida
Nacimiento
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/84082
Aporte de:
SEDICI (UNLP) de Universidad Nacional de La Plata
id I19-R120-10915-84082
record_format dspace
institution Universidad Nacional de La Plata
institution_str I-19
repository_str R-120
collection SEDICI (UNLP)
language Inglés
topic Ciencias Médicas
Talidomida
Nacimiento
spellingShingle Ciencias Médicas
Talidomida
Nacimiento
Vianna, Fernanda Sales Luiz
López Camelo, Jorge Santiago
Louguercio Leite, Júlio César
Vieira Sanseverino, Maria Teresa
Graça Dutra, Maria da
Castilla, Eduardo Enrique
Schüler Faccini, Lavínia
Epidemiological surveillance of birth defects compatible with thalidomide embryopathy in Brazil
topic_facet Ciencias Médicas
Talidomida
Nacimiento
description The thalidomide tragedy of the 1960s resulted in thousands of children being born with severe limb reduction defects (LRD), among other malformations. In Brazil, there are still babies born with thalidomide embryopathy (TE) because of leprosy prevalence, availability of thalidomide, and deficiencies in the control of drug dispensation. Our objective was to implement a system of proactive surveillance to identify birth defects compatible with TE. Along one year, newborns with LRD were assessed in the Brazilian hospitals participating in the Latin-American Collaborative Study of Congenital Malformations (ECLAMC). A phenotype of LRD called thalidomide embryopathy phenotype (TEP) was established for surveillance. Children with TEP born between the years 2000-2008 were monitored, and during the 2007-2008 period we clinically investigated in greater detail all cases with TEP (proactive period). The period from 1982 to 1999 was defined as the baseline period for the cumulative sum statistics. The frequency of TEP during the surveillance period, at 3.10/10,000 births (CI 95%: 2.50-3.70), was significantly higher than that observed in the baseline period (1.92/10,000 births; CI 95%: 1.60-2.20), and not uniformly distributed across different Brazilian regions. During the proactive surveillance (2007-2008), two cases of suspected TE were identified, although the two mothers had denied the use of the drug during pregnancy. Our results suggest that TEP has probably increased in recent years, which coincides with the period of greater thalidomide availability. Our proactive surveillance identified two newborns with suspected TE, proving to be a sensitive tool to detect TE. The high frequency of leprosy and the large use of thalidomide reinforce the need for a continuous monitoring of TEP across Brazil.
format Articulo
Articulo
author Vianna, Fernanda Sales Luiz
López Camelo, Jorge Santiago
Louguercio Leite, Júlio César
Vieira Sanseverino, Maria Teresa
Graça Dutra, Maria da
Castilla, Eduardo Enrique
Schüler Faccini, Lavínia
author_facet Vianna, Fernanda Sales Luiz
López Camelo, Jorge Santiago
Louguercio Leite, Júlio César
Vieira Sanseverino, Maria Teresa
Graça Dutra, Maria da
Castilla, Eduardo Enrique
Schüler Faccini, Lavínia
author_sort Vianna, Fernanda Sales Luiz
title Epidemiological surveillance of birth defects compatible with thalidomide embryopathy in Brazil
title_short Epidemiological surveillance of birth defects compatible with thalidomide embryopathy in Brazil
title_full Epidemiological surveillance of birth defects compatible with thalidomide embryopathy in Brazil
title_fullStr Epidemiological surveillance of birth defects compatible with thalidomide embryopathy in Brazil
title_full_unstemmed Epidemiological surveillance of birth defects compatible with thalidomide embryopathy in Brazil
title_sort epidemiological surveillance of birth defects compatible with thalidomide embryopathy in brazil
publishDate 2011
url http://sedici.unlp.edu.ar/handle/10915/84082
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