Two crystal forms of a helix-rich fatty acid- and retinol-binding protein, Na-FAR-1, from the parasitic nematode Necator americanus

Na-FAR-1 is an unusual -helix-rich fatty acid- and retinol-binding protein from Necator americanus, a blood-feeding intestinal parasitic nematode of humans. It belongs to the FAR protein family, which is unique to nematodes; no structural information is available to date for FAR proteins from parasi...

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Autores principales: Gabrielsen, Mads, Rey Burusco, María Florencia, Griffiths, Kate, Roe, Andrew J., Cooper, Alan, Smith, Brian O., Kennedy, Malcolm W., Córsico, Betina
Formato: Articulo
Lenguaje:Inglés
Publicado: 2012
Materias:
Ciencias Médicas
fatty acid- and retinol-binding proteins
Na-FAR-1
Necator americanus
parasitic nematodes
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/84080
Aporte de:
SEDICI (UNLP) de Universidad Nacional de La Plata
id I19-R120-10915-84080
record_format dspace
institution Universidad Nacional de La Plata
institution_str I-19
repository_str R-120
collection SEDICI (UNLP)
language Inglés
topic Ciencias Médicas
fatty acid- and retinol-binding proteins
Na-FAR-1
Necator americanus
parasitic nematodes
spellingShingle Ciencias Médicas
fatty acid- and retinol-binding proteins
Na-FAR-1
Necator americanus
parasitic nematodes
Gabrielsen, Mads
Rey Burusco, María Florencia
Griffiths, Kate
Roe, Andrew J.
Cooper, Alan
Smith, Brian O.
Kennedy, Malcolm W.
Córsico, Betina
Two crystal forms of a helix-rich fatty acid- and retinol-binding protein, Na-FAR-1, from the parasitic nematode Necator americanus
topic_facet Ciencias Médicas
fatty acid- and retinol-binding proteins
Na-FAR-1
Necator americanus
parasitic nematodes
description Na-FAR-1 is an unusual -helix-rich fatty acid- and retinol-binding protein from Necator americanus, a blood-feeding intestinal parasitic nematode of humans. It belongs to the FAR protein family, which is unique to nematodes; no structural information is available to date for FAR proteins from parasites. Crystals were obtained with two different morphologies that corresponded to different space groups. Crystal form 1 exhibited space group P432 (unit-cell parameters a = b = c = 120.80 Å, α = β = γ = 90°) and diffracted to 2.5 Å resolution, whereas crystal form 2 exhibited space group F23 (unit-cell parameters a = b = c = 240.38 Å, α = β = γ = 90°) and diffracted to 3.2 Å resolution. Crystal form 2 showed signs of significant twinning.
format Articulo
Articulo
author Gabrielsen, Mads
Rey Burusco, María Florencia
Griffiths, Kate
Roe, Andrew J.
Cooper, Alan
Smith, Brian O.
Kennedy, Malcolm W.
Córsico, Betina
author_facet Gabrielsen, Mads
Rey Burusco, María Florencia
Griffiths, Kate
Roe, Andrew J.
Cooper, Alan
Smith, Brian O.
Kennedy, Malcolm W.
Córsico, Betina
author_sort Gabrielsen, Mads
title Two crystal forms of a helix-rich fatty acid- and retinol-binding protein, Na-FAR-1, from the parasitic nematode Necator americanus
title_short Two crystal forms of a helix-rich fatty acid- and retinol-binding protein, Na-FAR-1, from the parasitic nematode Necator americanus
title_full Two crystal forms of a helix-rich fatty acid- and retinol-binding protein, Na-FAR-1, from the parasitic nematode Necator americanus
title_fullStr Two crystal forms of a helix-rich fatty acid- and retinol-binding protein, Na-FAR-1, from the parasitic nematode Necator americanus
title_full_unstemmed Two crystal forms of a helix-rich fatty acid- and retinol-binding protein, Na-FAR-1, from the parasitic nematode Necator americanus
title_sort two crystal forms of a helix-rich fatty acid- and retinol-binding protein, na-far-1, from the parasitic nematode necator americanus
publishDate 2012
url http://sedici.unlp.edu.ar/handle/10915/84080
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