Development and sedative effect of a new formulation of midazolam in chocolate bars

The aim of this work was to assess the stability and sedative effect of midazolam in chocolate bars. The stability of 5 g chocolate bars containing 6 mg midazolam hydrochloride was evaluated at room temperature (25 ± 2 °C), at 4 and 40 °C, by HPLC. Drug plasma levels were measured and the sedative e...

Descripción completa

Detalles Bibliográficos
Autores principales: Flores Pérez, Carmen, Juárez Olguín, Hugo, Flores Pérez, Janett, Ramírez Mendiola, Blanca, González Zamora, José F., Alemón Medina, Radamés, Rivera Espinosa, Liliana, Chávez Pacheco, Juan L.
Formato: Articulo
Lenguaje:Inglés
Publicado: 2011
Materias:
Farmacia
Cacao
Estabilidad de Medicamentos
Midazolam
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/8404
http://www.latamjpharm.org/resumenes/30/10/LAJOP_30_10_1_16.pdf
Aporte de:
SEDICI (UNLP) de Universidad Nacional de La Plata
id I19-R120-10915-8404
record_format dspace
institution Universidad Nacional de La Plata
institution_str I-19
repository_str R-120
collection SEDICI (UNLP)
language Inglés
topic Farmacia
Cacao
Estabilidad de Medicamentos
Midazolam
spellingShingle Farmacia
Cacao
Estabilidad de Medicamentos
Midazolam
Flores Pérez, Carmen
Juárez Olguín, Hugo
Flores Pérez, Janett
Ramírez Mendiola, Blanca
González Zamora, José F.
Alemón Medina, Radamés
Rivera Espinosa, Liliana
Chávez Pacheco, Juan L.
Development and sedative effect of a new formulation of midazolam in chocolate bars
topic_facet Farmacia
Cacao
Estabilidad de Medicamentos
Midazolam
description The aim of this work was to assess the stability and sedative effect of midazolam in chocolate bars. The stability of 5 g chocolate bars containing 6 mg midazolam hydrochloride was evaluated at room temperature (25 ± 2 °C), at 4 and 40 °C, by HPLC. Drug plasma levels were measured and the sedative effect was confirmed in six healthy volunteers according to the Ramsay’s scale. Data regarding chocolate bar administration were compared to those from the apple juice solution. Pharmacokinetic data were processed using the WinNonLin 5.2 software. Midazolam in chocolate bars remained stable for 14 days at room temperature and exposed to light; for 90 days at 4 and 40 °C protected from light, and showed a longer shelf life, better flavour and appearance, inducing the same sedative effect as the apple juice preparation. Raspberry flavour masked midazolam unpleasing taste most favourably.
format Articulo
Articulo
author Flores Pérez, Carmen
Juárez Olguín, Hugo
Flores Pérez, Janett
Ramírez Mendiola, Blanca
González Zamora, José F.
Alemón Medina, Radamés
Rivera Espinosa, Liliana
Chávez Pacheco, Juan L.
author_facet Flores Pérez, Carmen
Juárez Olguín, Hugo
Flores Pérez, Janett
Ramírez Mendiola, Blanca
González Zamora, José F.
Alemón Medina, Radamés
Rivera Espinosa, Liliana
Chávez Pacheco, Juan L.
author_sort Flores Pérez, Carmen
title Development and sedative effect of a new formulation of midazolam in chocolate bars
title_short Development and sedative effect of a new formulation of midazolam in chocolate bars
title_full Development and sedative effect of a new formulation of midazolam in chocolate bars
title_fullStr Development and sedative effect of a new formulation of midazolam in chocolate bars
title_full_unstemmed Development and sedative effect of a new formulation of midazolam in chocolate bars
title_sort development and sedative effect of a new formulation of midazolam in chocolate bars
publishDate 2011
url http://sedici.unlp.edu.ar/handle/10915/8404
http://www.latamjpharm.org/resumenes/30/10/LAJOP_30_10_1_16.pdf
work_keys_str_mv AT floresperezcarmen developmentandsedativeeffectofanewformulationofmidazolaminchocolatebars
AT juarezolguinhugo developmentandsedativeeffectofanewformulationofmidazolaminchocolatebars
AT floresperezjanett developmentandsedativeeffectofanewformulationofmidazolaminchocolatebars
AT ramirezmendiolablanca developmentandsedativeeffectofanewformulationofmidazolaminchocolatebars
AT gonzalezzamorajosef developmentandsedativeeffectofanewformulationofmidazolaminchocolatebars
AT alemonmedinaradames developmentandsedativeeffectofanewformulationofmidazolaminchocolatebars
AT riveraespinosaliliana developmentandsedativeeffectofanewformulationofmidazolaminchocolatebars
AT chavezpachecojuanl developmentandsedativeeffectofanewformulationofmidazolaminchocolatebars
bdutipo_str Repositorios
_version_ 1764820488316518401

Ejemplares similares