Design and development of gastro retentive drug delivery System of tramadol hydrochloride

The present investigation concerns the development of floating tablets of tramadol hydrochloride, which after oral administration are designed to prolong the gastric residence time; improves the drug bioavailability, reduces drug waste and diminish the side effects of drug. The D-optimal experimenta...

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Autores principales: Rathore, Devashish, Dahima, Rashmi
Formato: Articulo
Lenguaje:Inglés
Publicado: 2011
Materias:
Farmacia
Comprimidos
Tramadol
Sistemas de Liberación de Medicamentos
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/8402
http://www.latamjpharm.org/resumenes/30/10/LAJOP_30_10_1_14.pdf
Aporte de:
SEDICI (UNLP) de Universidad Nacional de La Plata
id I19-R120-10915-8402
record_format dspace
institution Universidad Nacional de La Plata
institution_str I-19
repository_str R-120
collection SEDICI (UNLP)
language Inglés
topic Farmacia
Comprimidos
Tramadol
Sistemas de Liberación de Medicamentos
spellingShingle Farmacia
Comprimidos
Tramadol
Sistemas de Liberación de Medicamentos
Rathore, Devashish
Dahima, Rashmi
Design and development of gastro retentive drug delivery System of tramadol hydrochloride
topic_facet Farmacia
Comprimidos
Tramadol
Sistemas de Liberación de Medicamentos
description The present investigation concerns the development of floating tablets of tramadol hydrochloride, which after oral administration are designed to prolong the gastric residence time; improves the drug bioavailability, reduces drug waste and diminish the side effects of drug. The D-optimal experimental design was employed to evaluate contribution of hydroxypropyl methyl cellulose (HPMC) K4M concentration, lactose concentration and kollidone SR concentration on drug release from floating tablets. Tablets were prepared using direct compression technique. Formulations were evaluated for in vitro buoyancy and drug release study using United States Pharmacopoeia (USP) 24 paddle type dissolution apparatus using 0.1 N HCl as dissolution medium. Multiple regression analysis was performed for factorial design batches to evaluate the response. All formulation had floating lag time below 2 min and constantly floated on dissolution medium for more than 24 h. It was found that optimized HPMC K4M (100 mg), kollidone SR (25 mg) and lactose (17.5 mg) have shown the release of 98.4 % in 22 h which was better as compare to marketed product (i.e. Tramazac-SR). Kinetic treatment to dissolution profiles revealed the diffusion mechanism so called as Fickian diffusion (Case I transport) which was mainly dependent on all the independent variables.
format Articulo
Articulo
author Rathore, Devashish
Dahima, Rashmi
author_facet Rathore, Devashish
Dahima, Rashmi
author_sort Rathore, Devashish
title Design and development of gastro retentive drug delivery System of tramadol hydrochloride
title_short Design and development of gastro retentive drug delivery System of tramadol hydrochloride
title_full Design and development of gastro retentive drug delivery System of tramadol hydrochloride
title_fullStr Design and development of gastro retentive drug delivery System of tramadol hydrochloride
title_full_unstemmed Design and development of gastro retentive drug delivery System of tramadol hydrochloride
title_sort design and development of gastro retentive drug delivery system of tramadol hydrochloride
publishDate 2011
url http://sedici.unlp.edu.ar/handle/10915/8402
http://www.latamjpharm.org/resumenes/30/10/LAJOP_30_10_1_14.pdf
work_keys_str_mv AT rathoredevashish designanddevelopmentofgastroretentivedrugdeliverysystemoftramadolhydrochloride
AT dahimarashmi designanddevelopmentofgastroretentivedrugdeliverysystemoftramadolhydrochloride
bdutipo_str Repositorios
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