Production and quenching of reactive oxygen species by pterin derivatives, an intriguing class of biomolecules

Pterins, a family of heterocyclic compounds derived from 2-aminopteridin-4(1H)-one, are widespread in living systems and participate in important biological functions, such as metabolic redox processes. Under UV-A excitation (320-400 nm), aromatic pterins (Pt) can generate reactive oxygen species (R...

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Detalles Bibliográficos
Autores principales:	Oliveros, Esther, Dántola, María Laura, Vignoni, Mariana, Thomas, Andrés Héctor, Lorente, Carolina
Formato:	Articulo
Lenguaje:	Inglés
Publicado:	2011
Materias:	Química Hydrogen peroxide Photochemical reactivity Pterin derivatives Quantum yields Rate constants Reactive oxygen species (ros) Singlet oxygen Superoxide anion
Acceso en línea:	http://sedici.unlp.edu.ar/handle/10915/83980
Aporte de:	SEDICI (UNLP) de Universidad Nacional de La Plata

id	I19-R120-10915-83980
record_format	dspace
institution	Universidad Nacional de La Plata
institution_str	I-19
repository_str	R-120
collection	SEDICI (UNLP)
language	Inglés
topic	Química Hydrogen peroxide Photochemical reactivity Pterin derivatives Quantum yields Rate constants Reactive oxygen species (ros) Singlet oxygen Superoxide anion
spellingShingle	Química Hydrogen peroxide Photochemical reactivity Pterin derivatives Quantum yields Rate constants Reactive oxygen species (ros) Singlet oxygen Superoxide anion Oliveros, Esther Dántola, María Laura Vignoni, Mariana Thomas, Andrés Héctor Lorente, Carolina Production and quenching of reactive oxygen species by pterin derivatives, an intriguing class of biomolecules
topic_facet	Química Hydrogen peroxide Photochemical reactivity Pterin derivatives Quantum yields Rate constants Reactive oxygen species (ros) Singlet oxygen Superoxide anion
description	Pterins, a family of heterocyclic compounds derived from 2-aminopteridin-4(1H)-one, are widespread in living systems and participate in important biological functions, such as metabolic redox processes. Under UV-A excitation (320-400 nm), aromatic pterins (Pt) can generate reactive oxygen species (ROS), as a consequence of both energy-and electron-transfer processes from their triplet excited state. Quantum yields of singlet oxygen (1O2) production depend largely on the nature of the substituents on the pterin moiety and on the pH. Formation of the superoxide anion by electron transfer between the pterin radical anion and molecular oxygen leads to the production of significant amounts of hydrogen peroxide (H2O2) by disproportionation. Dihydropterins (H2Pt) do not produce 1O2 but are oxidized by this species with high rate constants yielding pterins as well as H2O2. In contrast to aromatic derivatives, H2Pt are oxidized by H2O2, and rates and products strongly depend on the nature of the substituents on the H2Pt moiety. Aromatic pterins have been found in vivo under pathological conditions, e.g., biopterin or 6-carboxypterin are present in the skin of patients affected by vitiligo, a depigmentation disorder. The biomedical implications of the production of ROS by pterin derivatives and their reactivity with these species are discussed.
format	Articulo Articulo
author	Oliveros, Esther Dántola, María Laura Vignoni, Mariana Thomas, Andrés Héctor Lorente, Carolina
author_facet	Oliveros, Esther Dántola, María Laura Vignoni, Mariana Thomas, Andrés Héctor Lorente, Carolina
author_sort	Oliveros, Esther
title	Production and quenching of reactive oxygen species by pterin derivatives, an intriguing class of biomolecules
title_short	Production and quenching of reactive oxygen species by pterin derivatives, an intriguing class of biomolecules
title_full	Production and quenching of reactive oxygen species by pterin derivatives, an intriguing class of biomolecules
title_fullStr	Production and quenching of reactive oxygen species by pterin derivatives, an intriguing class of biomolecules
title_full_unstemmed	Production and quenching of reactive oxygen species by pterin derivatives, an intriguing class of biomolecules
title_sort	production and quenching of reactive oxygen species by pterin derivatives, an intriguing class of biomolecules
publishDate	2011
url	http://sedici.unlp.edu.ar/handle/10915/83980
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bdutipo_str	Repositorios
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Production and quenching of reactive oxygen species by pterin derivatives, an intriguing class of biomolecules

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