Identification of urinary and feces metabolites of Rhizoma Paridis saponins in rats based on ultra high performance liquid chromatography/time-of-flight mass spectrometry (UPLC/Q-TOF/MS)

An ultra-performance liquid chromatography/time-of-flight mass spectrometry (UPLC/QTOF/MS) method was established to analyze the saponins in Rhizoma Paridis saponins (RPS) and the constituents in urinary and feces samples. As we know, the constituents of traditional Chinese medicines are very comple...

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Detalles Bibliográficos
Autores principales: Wei, Jinchao, Liu, Changxiao, Man, Shuli, Gao, Wenyuan, Wu, Shanshan
Formato: Articulo
Lenguaje:Inglés
Publicado: 2011
Materias:
Farmacia
Cromatografía Liquida
Fenómenos Metabólicos
Rizoma
Saponinas
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/8397
http://www.latamjpharm.org/resumenes/30/10/LAJOP_30_10_1_9.pdf
Aporte de:
SEDICI (UNLP) de Universidad Nacional de La Plata
id I19-R120-10915-8397
record_format dspace
institution Universidad Nacional de La Plata
institution_str I-19
repository_str R-120
collection SEDICI (UNLP)
language Inglés
topic Farmacia
Cromatografía Liquida
Fenómenos Metabólicos
Rizoma
Saponinas
spellingShingle Farmacia
Cromatografía Liquida
Fenómenos Metabólicos
Rizoma
Saponinas
Wei, Jinchao
Liu, Changxiao
Man, Shuli
Gao, Wenyuan
Wu, Shanshan
Identification of urinary and feces metabolites of Rhizoma Paridis saponins in rats based on ultra high performance liquid chromatography/time-of-flight mass spectrometry (UPLC/Q-TOF/MS)
topic_facet Farmacia
Cromatografía Liquida
Fenómenos Metabólicos
Rizoma
Saponinas
description An ultra-performance liquid chromatography/time-of-flight mass spectrometry (UPLC/QTOF/MS) method was established to analyze the saponins in Rhizoma Paridis saponins (RPS) and the constituents in urinary and feces samples. As we know, the constituents of traditional Chinese medicines are very complex and pre-clinical research including metabolism, excretion and pharmacokinetics of herbal medicine components are of great importance in understanding their biological effects and safety. Therefore, deduction of the metabolic and excretive processes of RPS are necessary. As a result, twenty-two original saponins were detected in RPS-treated urinary and feces. Four excreta were observed in rat feces. Therefore, most original saponins and little deglycosylated saponins have been excreted in the rat urine and feces.
format Articulo
Articulo
author Wei, Jinchao
Liu, Changxiao
Man, Shuli
Gao, Wenyuan
Wu, Shanshan
author_facet Wei, Jinchao
Liu, Changxiao
Man, Shuli
Gao, Wenyuan
Wu, Shanshan
author_sort Wei, Jinchao
title Identification of urinary and feces metabolites of Rhizoma Paridis saponins in rats based on ultra high performance liquid chromatography/time-of-flight mass spectrometry (UPLC/Q-TOF/MS)
title_short Identification of urinary and feces metabolites of Rhizoma Paridis saponins in rats based on ultra high performance liquid chromatography/time-of-flight mass spectrometry (UPLC/Q-TOF/MS)
title_full Identification of urinary and feces metabolites of Rhizoma Paridis saponins in rats based on ultra high performance liquid chromatography/time-of-flight mass spectrometry (UPLC/Q-TOF/MS)
title_fullStr Identification of urinary and feces metabolites of Rhizoma Paridis saponins in rats based on ultra high performance liquid chromatography/time-of-flight mass spectrometry (UPLC/Q-TOF/MS)
title_full_unstemmed Identification of urinary and feces metabolites of Rhizoma Paridis saponins in rats based on ultra high performance liquid chromatography/time-of-flight mass spectrometry (UPLC/Q-TOF/MS)
title_sort identification of urinary and feces metabolites of rhizoma paridis saponins in rats based on ultra high performance liquid chromatography/time-of-flight mass spectrometry (uplc/q-tof/ms)
publishDate 2011
url http://sedici.unlp.edu.ar/handle/10915/8397
http://www.latamjpharm.org/resumenes/30/10/LAJOP_30_10_1_9.pdf
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