Chromosomal aberrations involving telomeres and interstitial telomeric sequences

Telomeres are specialised nucleoproteic complexes localised at the physical ends of linear eukaryotic chromosomes that maintain their stability and integrity. In vertebrate chromosomes, the DNA component of telomeres is constituted by (TTAGGG)n repeats, which can be localised at the terminal regions...

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Detalles Bibliográficos
Autor principal: Bolzán, Alejandro Daniel
Formato: Articulo Revision
Lenguaje:Inglés
Publicado: 2012
Materias:
Ciencias Naturales
Telomeres
Chromosomal aberrations
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/83969
Aporte de:
SEDICI (UNLP) de Universidad Nacional de La Plata
id I19-R120-10915-83969
record_format dspace
institution Universidad Nacional de La Plata
institution_str I-19
repository_str R-120
collection SEDICI (UNLP)
language Inglés
topic Ciencias Naturales
Telomeres
Chromosomal aberrations
spellingShingle Ciencias Naturales
Telomeres
Chromosomal aberrations
Bolzán, Alejandro Daniel
Chromosomal aberrations involving telomeres and interstitial telomeric sequences
topic_facet Ciencias Naturales
Telomeres
Chromosomal aberrations
description Telomeres are specialised nucleoproteic complexes localised at the physical ends of linear eukaryotic chromosomes that maintain their stability and integrity. In vertebrate chromosomes, the DNA component of telomeres is constituted by (TTAGGG)n repeats, which can be localised at the terminal regions of chromosomes (true telomeres) or at intrachromosomal sites (interstitial telomeric sequences or ITSs, located at the centromeric region or between the centromere and the telomere). In the past two decades, the use of molecular cytogenetic techniques has led to a new spectrum of spontaneous and clastogen-induced chromosomal aberrations being identified, involving telomeres and ITSs. Some aberrations involve the chromosome ends and, indirectly, the telomeric repeats located at the terminal regions of chromosomes (true telomeres). A second type of aberrations directly involves the telomeric sequences located at the chromosome ends. Finally, there is a third class of aberrations that specifically involves the ITSs. The aims of this review are to provide a detailed description of these aberrations and to summarise the available data regarding their induction by physical and chemical mutagens.
format Articulo
Revision
author Bolzán, Alejandro Daniel
author_facet Bolzán, Alejandro Daniel
author_sort Bolzán, Alejandro Daniel
title Chromosomal aberrations involving telomeres and interstitial telomeric sequences
title_short Chromosomal aberrations involving telomeres and interstitial telomeric sequences
title_full Chromosomal aberrations involving telomeres and interstitial telomeric sequences
title_fullStr Chromosomal aberrations involving telomeres and interstitial telomeric sequences
title_full_unstemmed Chromosomal aberrations involving telomeres and interstitial telomeric sequences
title_sort chromosomal aberrations involving telomeres and interstitial telomeric sequences
publishDate 2012
url http://sedici.unlp.edu.ar/handle/10915/83969
work_keys_str_mv AT bolzanalejandrodaniel chromosomalaberrationsinvolvingtelomeresandinterstitialtelomericsequences
bdutipo_str Repositorios
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