Pharmaceutical quality control studies on gatifloxacin 200 mg tablets available in the pakistani market

The aim of present work was to compare the quality of different brands of gatifloxacin 200 mg tablets, collected from different retail pharmacies in the local market of Pakistan. Five different brands were characterized by physical and chemical parameters such as, weight variation, hardness, thickne...

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Detalles Bibliográficos
Autores principales:	Khan, Ahmad, Hanif, Muhammad, Yousuf, Rabia I., Ghayas, Sana, Shoaib, Harris M., Arshad, Hafiz M.
Formato:	Articulo
Lenguaje:	Inglés
Publicado:	2011
Materias:	Farmacia biowaiver; BCS class I; gatifloxacin; model-independent and model-dependent methods Control de Calidad antibiótico Fluoroquinolonas
Acceso en línea:	http://sedici.unlp.edu.ar/handle/10915/8396 http://www.latamjpharm.org/resumenes/30/10/LAJOP_30_10_1_8.pdf
Aporte de:	SEDICI (UNLP) de Universidad Nacional de La Plata

id	I19-R120-10915-8396
record_format	dspace
institution	Universidad Nacional de La Plata
institution_str	I-19
repository_str	R-120
collection	SEDICI (UNLP)
language	Inglés
topic	Farmacia biowaiver; BCS class I; gatifloxacin; model-independent and model-dependent methods Control de Calidad antibiótico Fluoroquinolonas
spellingShingle	Farmacia biowaiver; BCS class I; gatifloxacin; model-independent and model-dependent methods Control de Calidad antibiótico Fluoroquinolonas Khan, Ahmad Hanif, Muhammad Yousuf, Rabia I. Ghayas, Sana Shoaib, Harris M. Arshad, Hafiz M. Pharmaceutical quality control studies on gatifloxacin 200 mg tablets available in the pakistani market
topic_facet	Farmacia biowaiver; BCS class I; gatifloxacin; model-independent and model-dependent methods Control de Calidad antibiótico Fluoroquinolonas
description	The aim of present work was to compare the quality of different brands of gatifloxacin 200 mg tablets, collected from different retail pharmacies in the local market of Pakistan. Five different brands were characterized by physical and chemical parameters such as, weight variation, hardness, thickness, friability, disintegration, dissolution, uniformity of contents and assay. Among them dissolution either single point or multiple point, including release profile comparison is most important tool for establishing the quality of the product. Brand A was considered as a reference because it passed all physical, chemical, quality control test and it was also brand leader, while brands B, C, D and E were test brands due to their production in local pharmaceutical. Quality control tests were satisfactory and within the limits for all test brands. The aim either biowaiver study of all the brands should conduct or not the similarity and difference among the brands were measured. Results revealed that brand B and D shown the best similarity with brand A and least differential value when we used the model independent f2 factor for similarity and f1 factor for difference. Model dependent methods Zero order, First order, Higuchi release model and Hixson-Crowell method were also used and shown the concentration dependent release of drug, i.e. first order kinetic. The results showed that model-dependent methods were more discriminative than model-independent method. A criterion for selecting the most appropriate model was based on linearity (coefficient of correlation).
format	Articulo Articulo
author	Khan, Ahmad Hanif, Muhammad Yousuf, Rabia I. Ghayas, Sana Shoaib, Harris M. Arshad, Hafiz M.
author_facet	Khan, Ahmad Hanif, Muhammad Yousuf, Rabia I. Ghayas, Sana Shoaib, Harris M. Arshad, Hafiz M.
author_sort	Khan, Ahmad
title	Pharmaceutical quality control studies on gatifloxacin 200 mg tablets available in the pakistani market
title_short	Pharmaceutical quality control studies on gatifloxacin 200 mg tablets available in the pakistani market
title_full	Pharmaceutical quality control studies on gatifloxacin 200 mg tablets available in the pakistani market
title_fullStr	Pharmaceutical quality control studies on gatifloxacin 200 mg tablets available in the pakistani market
title_full_unstemmed	Pharmaceutical quality control studies on gatifloxacin 200 mg tablets available in the pakistani market
title_sort	pharmaceutical quality control studies on gatifloxacin 200 mg tablets available in the pakistani market
publishDate	2011
url	http://sedici.unlp.edu.ar/handle/10915/8396 http://www.latamjpharm.org/resumenes/30/10/LAJOP_30_10_1_8.pdf
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Pharmaceutical quality control studies on gatifloxacin 200 mg tablets available in the pakistani market

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