Assessment of solubility and intestinal absorption in vitro of praziquantel in solid dispersions of polyethylene glycol 6000

The aim of this study was to investigate the impact of solid dispersions of polyethylene glycol 6000 (PEG 6000), using the co-precipitation method, on the in vitro solubility and intestinal absorption of praziquantel (PZQ). The solubility of PZQ in solid dispersions and physical mixtures was assesse...

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Autores principales:	Chaud, Marco Vinicius, Paula, Fábio C., Moraes, Larissa C., Goes, Arielly L., Granato, Márcia M., Junior, José M.O., Zaparoli, Roney E., Vila, Marta M. D. C., Corrêa, Eliane M.
Formato:	Articulo
Lenguaje:	Inglés
Publicado:	2011
Materias:	Farmacia Solubilidad Praziquantel Glicoles de Polietileno Absorción Intestinal
Acceso en línea:	http://sedici.unlp.edu.ar/handle/10915/8394 http://www.latamjpharm.org/resumenes/30/10/LAJOP_30_10_1_6.pdf
Aporte de:	SEDICI (UNLP) de Universidad Nacional de La Plata

id	I19-R120-10915-8394
record_format	dspace
institution	Universidad Nacional de La Plata
institution_str	I-19
repository_str	R-120
collection	SEDICI (UNLP)
language	Inglés
topic	Farmacia Solubilidad Praziquantel Glicoles de Polietileno Absorción Intestinal
spellingShingle	Farmacia Solubilidad Praziquantel Glicoles de Polietileno Absorción Intestinal Chaud, Marco Vinicius Paula, Fábio C. Moraes, Larissa C. Goes, Arielly L. Granato, Márcia M. Junior, José M.O. Zaparoli, Roney E. Vila, Marta M. D. C. Corrêa, Eliane M. Assessment of solubility and intestinal absorption in vitro of praziquantel in solid dispersions of polyethylene glycol 6000
topic_facet	Farmacia Solubilidad Praziquantel Glicoles de Polietileno Absorción Intestinal
description	The aim of this study was to investigate the impact of solid dispersions of polyethylene glycol 6000 (PEG 6000), using the co-precipitation method, on the in vitro solubility and intestinal absorption of praziquantel (PZQ). The solubility of PZQ in solid dispersions and physical mixtures was assessed in purified water and TC-199 buffer. The everted intestinal sac model was employed to assess, in vitro, intestinal absorption of PZQ. A significant enhancement in both in vitro solubility and intestinal absorption of PZQ was found in solid dispersions compared to pure PZQ and physical mixtures. This positive series of preliminary results showed that solid dispersion of PEG 6000 is a valuable strategy for increasing bioavailability of PZQ and could also prove useful for other poorly water-soluble drugs.
format	Articulo Articulo
author	Chaud, Marco Vinicius Paula, Fábio C. Moraes, Larissa C. Goes, Arielly L. Granato, Márcia M. Junior, José M.O. Zaparoli, Roney E. Vila, Marta M. D. C. Corrêa, Eliane M.
author_facet	Chaud, Marco Vinicius Paula, Fábio C. Moraes, Larissa C. Goes, Arielly L. Granato, Márcia M. Junior, José M.O. Zaparoli, Roney E. Vila, Marta M. D. C. Corrêa, Eliane M.
author_sort	Chaud, Marco Vinicius
title	Assessment of solubility and intestinal absorption in vitro of praziquantel in solid dispersions of polyethylene glycol 6000
title_short	Assessment of solubility and intestinal absorption in vitro of praziquantel in solid dispersions of polyethylene glycol 6000
title_full	Assessment of solubility and intestinal absorption in vitro of praziquantel in solid dispersions of polyethylene glycol 6000
title_fullStr	Assessment of solubility and intestinal absorption in vitro of praziquantel in solid dispersions of polyethylene glycol 6000
title_full_unstemmed	Assessment of solubility and intestinal absorption in vitro of praziquantel in solid dispersions of polyethylene glycol 6000
title_sort	assessment of solubility and intestinal absorption in vitro of praziquantel in solid dispersions of polyethylene glycol 6000
publishDate	2011
url	http://sedici.unlp.edu.ar/handle/10915/8394 http://www.latamjpharm.org/resumenes/30/10/LAJOP_30_10_1_6.pdf
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Assessment of solubility and intestinal absorption in vitro of praziquantel in solid dispersions of polyethylene glycol 6000

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