Evaluation of the effect of drug solubility behaviour on the rate of release from the hydrophilic matrix system

To select the suitable concentration level of controlled release polymer for the formulation of predefined extended release formulation based on the solubility behaviour of active substance, we have formulated and evaluated the extended release matrix tablets of two different antihypertensive drugs...

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Detalles Bibliográficos
Autores principales:	Eaga, Chandramohan, Nageswara Reddy, M.V.V., Kumar Narla, Santosh
Formato:	Articulo Comunicacion
Lenguaje:	Inglés
Publicado:	2011
Materias:	Farmacia extended release; hypromellose K200M; metoprolol succinate; POLYOX WSR-303; propranolol hydrochloride
Acceso en línea:	http://sedici.unlp.edu.ar/handle/10915/8388 http://www.latamjpharm.org/resumenes/30/9/LAJOP_30_9_2_5.pdf
Aporte de:	SEDICI (UNLP) de Universidad Nacional de La Plata

id	I19-R120-10915-8388
record_format	dspace
institution	Universidad Nacional de La Plata
institution_str	I-19
repository_str	R-120
collection	SEDICI (UNLP)
language	Inglés
topic	Farmacia extended release; hypromellose K200M; metoprolol succinate; POLYOX WSR-303; propranolol hydrochloride
spellingShingle	Farmacia extended release; hypromellose K200M; metoprolol succinate; POLYOX WSR-303; propranolol hydrochloride Eaga, Chandramohan Nageswara Reddy, M.V.V. Kumar Narla, Santosh Evaluation of the effect of drug solubility behaviour on the rate of release from the hydrophilic matrix system
topic_facet	Farmacia extended release; hypromellose K200M; metoprolol succinate; POLYOX WSR-303; propranolol hydrochloride
description	To select the suitable concentration level of controlled release polymer for the formulation of predefined extended release formulation based on the solubility behaviour of active substance, we have formulated and evaluated the extended release matrix tablets of two different antihypertensive drugs having different solubility profile by direct compression process. The selected antihypertensive drugs are metoprolol succinate of freely soluble category and propranolol hydrochloride of soluble category (solubility in terms of water). The selected drugs were formulated with various concentrations of selected highest viscosity grades of controlled release polymers viz. HPMC K200M & Polyox WSR 303 and evaluated for drug release profile. Dissolution methods were conducted using USP official methods. From the studies conducted it was found that drug solubility behavior also plays an important role in selection of controlled release polymer concentration for formulation of extended release formulation and observed that a higher concentration level of controlled release polymer is required for the formulation of freely soluble drug than soluble drug.
format	Articulo Comunicacion
author	Eaga, Chandramohan Nageswara Reddy, M.V.V. Kumar Narla, Santosh
author_facet	Eaga, Chandramohan Nageswara Reddy, M.V.V. Kumar Narla, Santosh
author_sort	Eaga, Chandramohan
title	Evaluation of the effect of drug solubility behaviour on the rate of release from the hydrophilic matrix system
title_short	Evaluation of the effect of drug solubility behaviour on the rate of release from the hydrophilic matrix system
title_full	Evaluation of the effect of drug solubility behaviour on the rate of release from the hydrophilic matrix system
title_fullStr	Evaluation of the effect of drug solubility behaviour on the rate of release from the hydrophilic matrix system
title_full_unstemmed	Evaluation of the effect of drug solubility behaviour on the rate of release from the hydrophilic matrix system
title_sort	evaluation of the effect of drug solubility behaviour on the rate of release from the hydrophilic matrix system
publishDate	2011
url	http://sedici.unlp.edu.ar/handle/10915/8388 http://www.latamjpharm.org/resumenes/30/9/LAJOP_30_9_2_5.pdf
work_keys_str_mv	AT eagachandramohan evaluationoftheeffectofdrugsolubilitybehaviourontherateofreleasefromthehydrophilicmatrixsystem AT nageswarareddymvv evaluationoftheeffectofdrugsolubilitybehaviourontherateofreleasefromthehydrophilicmatrixsystem AT kumarnarlasantosh evaluationoftheeffectofdrugsolubilitybehaviourontherateofreleasefromthehydrophilicmatrixsystem
bdutipo_str	Repositorios
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Evaluation of the effect of drug solubility behaviour on the rate of release from the hydrophilic matrix system

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