Development and characterization of biodegradable chitosan nanoparticles loaded with lovastatin using factorial design

The objective of the present work was to formulate chitosan nanoparticles as carriers for the lovastatin, since this drug undergoes extensive first pass extraction in the liver, and bioavailibity is low (< 5 %). Nanoparticles were prepared by modified ionotropic gelation method using 32 full fact...

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Detalles Bibliográficos
Autores principales: More, Harinath N., Shinde, Anilkumar J.
Formato: Articulo
Lenguaje:Español
Publicado: 2011
Materias:
Farmacia
Administración Oral
Sistemas de Liberación de Medicamentos
Lovastatina
Quitosana
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/8380
http://www.latamjpharm.org/resumenes/30/9/LAJOP_30_9_1_24.pdf
Aporte de:
SEDICI (UNLP) de Universidad Nacional de La Plata
id I19-R120-10915-8380
record_format dspace
institution Universidad Nacional de La Plata
institution_str I-19
repository_str R-120
collection SEDICI (UNLP)
language Español
topic Farmacia
Administración Oral
Sistemas de Liberación de Medicamentos
Lovastatina
Quitosana
spellingShingle Farmacia
Administración Oral
Sistemas de Liberación de Medicamentos
Lovastatina
Quitosana
More, Harinath N.
Shinde, Anilkumar J.
Development and characterization of biodegradable chitosan nanoparticles loaded with lovastatin using factorial design
topic_facet Farmacia
Administración Oral
Sistemas de Liberación de Medicamentos
Lovastatina
Quitosana
description The objective of the present work was to formulate chitosan nanoparticles as carriers for the lovastatin, since this drug undergoes extensive first pass extraction in the liver, and bioavailibity is low (< 5 %). Nanoparticles were prepared by modified ionotropic gelation method using 32 full factorial design. From the preliminary trials, the constraints for independent variables X1 (concentration of chitosan) and X2 (concentration of sodium tripolyphosphate) have been fixed and examined to investigate effect on particle size, encapsulation efficiency, zeta potential, % release, SEM, FTIR, XRD and DSC analysis of lovastatin. The diameter of prepared nanoparticles was controlled in the range of 100-800 nm, spherical shape and narrow diameter distribution. The release profiles of all batches were very well fitted by both the zero order model and the anomalous transport. These results indicate that lovastatin nanoparticles could be effective in sustaining drug release for a prolonged period.
format Articulo
Articulo
author More, Harinath N.
Shinde, Anilkumar J.
author_facet More, Harinath N.
Shinde, Anilkumar J.
author_sort More, Harinath N.
title Development and characterization of biodegradable chitosan nanoparticles loaded with lovastatin using factorial design
title_short Development and characterization of biodegradable chitosan nanoparticles loaded with lovastatin using factorial design
title_full Development and characterization of biodegradable chitosan nanoparticles loaded with lovastatin using factorial design
title_fullStr Development and characterization of biodegradable chitosan nanoparticles loaded with lovastatin using factorial design
title_full_unstemmed Development and characterization of biodegradable chitosan nanoparticles loaded with lovastatin using factorial design
title_sort development and characterization of biodegradable chitosan nanoparticles loaded with lovastatin using factorial design
publishDate 2011
url http://sedici.unlp.edu.ar/handle/10915/8380
http://www.latamjpharm.org/resumenes/30/9/LAJOP_30_9_1_24.pdf
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AT shindeanilkumarj developmentandcharacterizationofbiodegradablechitosannanoparticlesloadedwithlovastatinusingfactorialdesign
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