Preparation and characterisation of controlled release ciprofloxacin HCl microspheres

The aim of the study was to formulate and evaluate controlled release microspheres. Ciprofloxacin HCl, belonging to the class of fluroquinolones, was chosen as the model drug. The drugloaded microspheres were prepared with different ratios of polymers like sodium alginate and sodium carboxy methyl c...

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Detalles Bibliográficos
Autores principales: Bhat, Sudeendra R., Roopa, G.
Formato: Articulo
Lenguaje:Inglés
Publicado: 2011
Materias:
Farmacia
Sodio
Microesferas
Ciprofloxacino
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/8379
http://www.latamjpharm.org/resumenes/30/9/LAJOP_30_9_1_23.pdf
Aporte de:
SEDICI (UNLP) de Universidad Nacional de La Plata
id I19-R120-10915-8379
record_format dspace
institution Universidad Nacional de La Plata
institution_str I-19
repository_str R-120
collection SEDICI (UNLP)
language Inglés
topic Farmacia
Sodio
Microesferas
Ciprofloxacino
spellingShingle Farmacia
Sodio
Microesferas
Ciprofloxacino
Bhat, Sudeendra R.
Roopa, G.
Preparation and characterisation of controlled release ciprofloxacin HCl microspheres
topic_facet Farmacia
Sodio
Microesferas
Ciprofloxacino
description The aim of the study was to formulate and evaluate controlled release microspheres. Ciprofloxacin HCl, belonging to the class of fluroquinolones, was chosen as the model drug. The drugloaded microspheres were prepared with different ratios of polymers like sodium alginate and sodium carboxy methyl cellulose (CMC) by w/o emulsification solvent evaporation method. The prepared microspheres were characterized by FT-IR spectroscopy, differential scanning colorimetry for drug polymer compatibility studies and scanning electron microscopy for surface morphology. The resulting microspheres were found to be small, discrete, spherical and free flowing. They were further evaluated for their micromeritic properties, particle size analysis, drug loading and entrapment efficiency. The mean particle size was 201.21 μm. In vitro drug release studies revealed that formulation Fm6 containing sodium CMC as the polymer showed greater sustained effect for 10 hours. Stability studies showed no significant changes in the drug content and physical appearance.
format Articulo
Articulo
author Bhat, Sudeendra R.
Roopa, G.
author_facet Bhat, Sudeendra R.
Roopa, G.
author_sort Bhat, Sudeendra R.
title Preparation and characterisation of controlled release ciprofloxacin HCl microspheres
title_short Preparation and characterisation of controlled release ciprofloxacin HCl microspheres
title_full Preparation and characterisation of controlled release ciprofloxacin HCl microspheres
title_fullStr Preparation and characterisation of controlled release ciprofloxacin HCl microspheres
title_full_unstemmed Preparation and characterisation of controlled release ciprofloxacin HCl microspheres
title_sort preparation and characterisation of controlled release ciprofloxacin hcl microspheres
publishDate 2011
url http://sedici.unlp.edu.ar/handle/10915/8379
http://www.latamjpharm.org/resumenes/30/9/LAJOP_30_9_1_23.pdf
work_keys_str_mv AT bhatsudeendrar preparationandcharacterisationofcontrolledreleaseciprofloxacinhclmicrospheres
AT roopag preparationandcharacterisationofcontrolledreleaseciprofloxacinhclmicrospheres
bdutipo_str Repositorios
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