Formulation and evaluation of gliclazide loaded controlled release microspheres

The aim of this study was to formulate gliclazide loaded controlled release microspheres. Microspheres were prepared by quasi emulsion solvent diffusion technique using eudragit RLPO, eudragit RSPO and with their various combinations. The effect of different formulation variables (drug-polymer ratio...

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Autores principales: Dey, Sanjay, Mohanta, Bibhash C., Das Gupta, Sandipan, Mazumder, Bhaskar
Formato: Articulo
Lenguaje:Inglés
Publicado: 2011
Materias:
Farmacia
Hipoglucemia
Gliclazida
Microesferas
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/8371
http://www.latamjpharm.org/resumenes/30/9/LAJOP_30_9_1_15.pdf
Aporte de:
SEDICI (UNLP) de Universidad Nacional de La Plata
id I19-R120-10915-8371
record_format dspace
institution Universidad Nacional de La Plata
institution_str I-19
repository_str R-120
collection SEDICI (UNLP)
language Inglés
topic Farmacia
Hipoglucemia
Gliclazida
Microesferas
spellingShingle Farmacia
Hipoglucemia
Gliclazida
Microesferas
Dey, Sanjay
Mohanta, Bibhash C.
Das Gupta, Sandipan
Mazumder, Bhaskar
Formulation and evaluation of gliclazide loaded controlled release microspheres
topic_facet Farmacia
Hipoglucemia
Gliclazida
Microesferas
description The aim of this study was to formulate gliclazide loaded controlled release microspheres. Microspheres were prepared by quasi emulsion solvent diffusion technique using eudragit RLPO, eudragit RSPO and with their various combinations. The effect of different formulation variables (drug-polymer ratio and polymer-polymer ratio) on percent yield, mean particle size, encapsulation efficiency and in vitro release of drug were evaluated. In vivo test of the optimized formulation was performed on streptozotocin induced type-2 diabetic rat model. The formulated microspheres showed higher encapsulation efficiencies within the range of 72-84 %. Mean particle size, encapsulation efficiency and in vitro release were found to be affected by changing in formulation variables. In vitro release study revealed the gliclazide release from the microspheres was extended for more than 12 h. In vivo hypoglycemic effect of microspheres was more than 25 h suggesting microspheres are a valuable system for sustained delivery of gliclazide.
format Articulo
Articulo
author Dey, Sanjay
Mohanta, Bibhash C.
Das Gupta, Sandipan
Mazumder, Bhaskar
author_facet Dey, Sanjay
Mohanta, Bibhash C.
Das Gupta, Sandipan
Mazumder, Bhaskar
author_sort Dey, Sanjay
title Formulation and evaluation of gliclazide loaded controlled release microspheres
title_short Formulation and evaluation of gliclazide loaded controlled release microspheres
title_full Formulation and evaluation of gliclazide loaded controlled release microspheres
title_fullStr Formulation and evaluation of gliclazide loaded controlled release microspheres
title_full_unstemmed Formulation and evaluation of gliclazide loaded controlled release microspheres
title_sort formulation and evaluation of gliclazide loaded controlled release microspheres
publishDate 2011
url http://sedici.unlp.edu.ar/handle/10915/8371
http://www.latamjpharm.org/resumenes/30/9/LAJOP_30_9_1_15.pdf
work_keys_str_mv AT deysanjay formulationandevaluationofgliclazideloadedcontrolledreleasemicrospheres
AT mohantabibhashc formulationandevaluationofgliclazideloadedcontrolledreleasemicrospheres
AT dasguptasandipan formulationandevaluationofgliclazideloadedcontrolledreleasemicrospheres
AT mazumderbhaskar formulationandevaluationofgliclazideloadedcontrolledreleasemicrospheres
bdutipo_str Repositorios
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