Effect of oral administration of D-004, a lipid extract from Roystonea regia Fruits, on xylene-induced ear oedema in mice

D-004, a lipid extract from Roystonea regia fruits, consists in a mixture of free fatty acids, mainly of oleic, lauric, myristic and palmitic acids, whereas other free fatty acids are present in minor proportions. D-004 has been shown to reduce experimentally-induced prostate hyperplasia and to prod...

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Detalles Bibliográficos
Autores principales:	Ravelo, Yazmin, Molina, Vivian, Jiménez, Sonia, Oyarzábal, Ambar, Pérez, Yohani, Más, Rosa
Formato:	Articulo
Lenguaje:	Inglés
Publicado:	2011
Materias:	Farmacia D-004; inflammation; myeloperoxidase; xylene-induced oedema
Acceso en línea:	http://sedici.unlp.edu.ar/handle/10915/8368 http://www.latamjpharm.org/resumenes/30/9/LAJOP_30_9_1_12.pdf
Aporte de:	SEDICI (UNLP) de Universidad Nacional de La Plata

id	I19-R120-10915-8368
record_format	dspace
institution	Universidad Nacional de La Plata
institution_str	I-19
repository_str	R-120
collection	SEDICI (UNLP)
language	Inglés
topic	Farmacia D-004; inflammation; myeloperoxidase; xylene-induced oedema
spellingShingle	Farmacia D-004; inflammation; myeloperoxidase; xylene-induced oedema Ravelo, Yazmin Molina, Vivian Jiménez, Sonia Oyarzábal, Ambar Pérez, Yohani Más, Rosa Effect of oral administration of D-004, a lipid extract from Roystonea regia Fruits, on xylene-induced ear oedema in mice
topic_facet	Farmacia D-004; inflammation; myeloperoxidase; xylene-induced oedema
description	D-004, a lipid extract from Roystonea regia fruits, consists in a mixture of free fatty acids, mainly of oleic, lauric, myristic and palmitic acids, whereas other free fatty acids are present in minor proportions. D-004 has been shown to reduce experimentally-induced prostate hyperplasia and to produce anti-inflammatory effects in a chronic inflammation model. The effects of D-004 on models of acute inflammation, however, have not been explored. This study investigated the effects of single oral doses of D-004 on the model of xylene-induced ear mice oedema. Mice were distributed into 6 experimental groups: one negative control and five xylene-treated groups: one positive control (vehicle), three treated with D-004 (100, 400 and 800 mg/kg) and one with indomethacin (10 mg/kg). Effects on oedema formation and myeloperoxidase (MPO) activity were assessed. D-004 at 400 and 800 mg/kg significantly reduced both variables. The reduction of MPO activity, not of oedema formation, was dose-dependent. Concluding, D- 004 was effective as anti-inflammatory drug on the xylene-induced ear mice oedema, a model of acute inflammation.
format	Articulo Articulo
author	Ravelo, Yazmin Molina, Vivian Jiménez, Sonia Oyarzábal, Ambar Pérez, Yohani Más, Rosa
author_facet	Ravelo, Yazmin Molina, Vivian Jiménez, Sonia Oyarzábal, Ambar Pérez, Yohani Más, Rosa
author_sort	Ravelo, Yazmin
title	Effect of oral administration of D-004, a lipid extract from Roystonea regia Fruits, on xylene-induced ear oedema in mice
title_short	Effect of oral administration of D-004, a lipid extract from Roystonea regia Fruits, on xylene-induced ear oedema in mice
title_full	Effect of oral administration of D-004, a lipid extract from Roystonea regia Fruits, on xylene-induced ear oedema in mice
title_fullStr	Effect of oral administration of D-004, a lipid extract from Roystonea regia Fruits, on xylene-induced ear oedema in mice
title_full_unstemmed	Effect of oral administration of D-004, a lipid extract from Roystonea regia Fruits, on xylene-induced ear oedema in mice
title_sort	effect of oral administration of d-004, a lipid extract from roystonea regia fruits, on xylene-induced ear oedema in mice
publishDate	2011
url	http://sedici.unlp.edu.ar/handle/10915/8368 http://www.latamjpharm.org/resumenes/30/9/LAJOP_30_9_1_12.pdf
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bdutipo_str	Repositorios
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Effect of oral administration of D-004, a lipid extract from Roystonea regia Fruits, on xylene-induced ear oedema in mice

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