Solubility and stability studies of benzoyl peroxide in non-polar, non-comedogenic solvents for use in topical pharmaceutical formulation developments

Non-irritant, non-comedogenic and non-polar emollients were pre-selected for determinations of relative dielectric permittivity and solubility of benzoyl peroxide (BP). Those solvents capable of solubilizing BP in concentrations commonly utilised in topical formulations (between 1 and 10 %) were tak...

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Autores principales: Acevedo, María E., Fernández, Adriana, Pasquali, Ricardo C., Sorichetti, Patricio A., Serrao, Rosa, Bregni, Carlos, Mouriño, Viviana S.
Formato: Articulo
Lenguaje:Inglés
Publicado: 2011
Materias:
Farmacia
Peróxido de Benzoílo
Solubilidad
Estabilidad de Medicamentos
Termodinámica
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/8367
http://www.latamjpharm.org/resumenes/30/9/LAJOP_30_9_1_11.pdf
Aporte de:
SEDICI (UNLP) de Universidad Nacional de La Plata
id I19-R120-10915-8367
record_format dspace
institution Universidad Nacional de La Plata
institution_str I-19
repository_str R-120
collection SEDICI (UNLP)
language Inglés
topic Farmacia
Peróxido de Benzoílo
Solubilidad
Estabilidad de Medicamentos
Termodinámica
spellingShingle Farmacia
Peróxido de Benzoílo
Solubilidad
Estabilidad de Medicamentos
Termodinámica
Acevedo, María E.
Fernández, Adriana
Pasquali, Ricardo C.
Sorichetti, Patricio A.
Serrao, Rosa
Bregni, Carlos
Mouriño, Viviana S.
Solubility and stability studies of benzoyl peroxide in non-polar, non-comedogenic solvents for use in topical pharmaceutical formulation developments
topic_facet Farmacia
Peróxido de Benzoílo
Solubilidad
Estabilidad de Medicamentos
Termodinámica
description Non-irritant, non-comedogenic and non-polar emollients were pre-selected for determinations of relative dielectric permittivity and solubility of benzoyl peroxide (BP). Those solvents capable of solubilizing BP in concentrations commonly utilised in topical formulations (between 1 and 10 %) were taken into account for stability studies. The developed pre-formulations were also studied for acute irritation both clinically and instrumentally. Even though the solubility of BP in the solvents studied had relatively low values; in some cases, such as with caprylic/capric triglyceride (CapCap) and dicaprylyl carbonate (DicCar) it has been possible to obtain acceptable concentrations of BP from a therapeutic viewpoint (19.9 and 19.5 mg/mL, respectively). Two BP pre-formulations (PBCapCap and PBDicCar) with enhanced stability and with the capability to decrease adverse application site reaction by maintaining moisture in the stratum corneum were developed with potential application in topical formulations of BP with solvents of low relative dielectric permittivity (CapCap and DicCar, respectively).
format Articulo
Articulo
author Acevedo, María E.
Fernández, Adriana
Pasquali, Ricardo C.
Sorichetti, Patricio A.
Serrao, Rosa
Bregni, Carlos
Mouriño, Viviana S.
author_facet Acevedo, María E.
Fernández, Adriana
Pasquali, Ricardo C.
Sorichetti, Patricio A.
Serrao, Rosa
Bregni, Carlos
Mouriño, Viviana S.
author_sort Acevedo, María E.
title Solubility and stability studies of benzoyl peroxide in non-polar, non-comedogenic solvents for use in topical pharmaceutical formulation developments
title_short Solubility and stability studies of benzoyl peroxide in non-polar, non-comedogenic solvents for use in topical pharmaceutical formulation developments
title_full Solubility and stability studies of benzoyl peroxide in non-polar, non-comedogenic solvents for use in topical pharmaceutical formulation developments
title_fullStr Solubility and stability studies of benzoyl peroxide in non-polar, non-comedogenic solvents for use in topical pharmaceutical formulation developments
title_full_unstemmed Solubility and stability studies of benzoyl peroxide in non-polar, non-comedogenic solvents for use in topical pharmaceutical formulation developments
title_sort solubility and stability studies of benzoyl peroxide in non-polar, non-comedogenic solvents for use in topical pharmaceutical formulation developments
publishDate 2011
url http://sedici.unlp.edu.ar/handle/10915/8367
http://www.latamjpharm.org/resumenes/30/9/LAJOP_30_9_1_11.pdf
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