Influence of surfactant structure in the encapsulation and stability of amphotericin B in niosomes

Bilayer vesicles, such as liposomes and niosomes, are widely known as efficient delivery systems for drugs. Spherical vesicles consisting of amphipatic non-ionic surfactants named niosomes are arranged in one or more concentric bilayers. They can entrap both water and oil soluble substances in the i...

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Autores principales: Salerno, Claudia, Chiappetta, Diego A., Monteagudo, Ezequiel, Bregni, Carlos
Formato: Articulo
Lenguaje:Inglés
Publicado: 2011
Materias:
Farmacia
Anfotericina B
niosomes; non- ionic surfactant; vesicular systems
Sistemas de Administración de Bases de Datos
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/8366
http://www.latamjpharm.org/resumenes/30/9/LAJOP_30_9_1_10.pdf
Aporte de:
SEDICI (UNLP) de Universidad Nacional de La Plata
id I19-R120-10915-8366
record_format dspace
institution Universidad Nacional de La Plata
institution_str I-19
repository_str R-120
collection SEDICI (UNLP)
language Inglés
topic Farmacia
Anfotericina B
niosomes; non- ionic surfactant; vesicular systems
Sistemas de Administración de Bases de Datos
spellingShingle Farmacia
Anfotericina B
niosomes; non- ionic surfactant; vesicular systems
Sistemas de Administración de Bases de Datos
Salerno, Claudia
Chiappetta, Diego A.
Monteagudo, Ezequiel
Bregni, Carlos
Influence of surfactant structure in the encapsulation and stability of amphotericin B in niosomes
topic_facet Farmacia
Anfotericina B
niosomes; non- ionic surfactant; vesicular systems
Sistemas de Administración de Bases de Datos
description Bilayer vesicles, such as liposomes and niosomes, are widely known as efficient delivery systems for drugs. Spherical vesicles consisting of amphipatic non-ionic surfactants named niosomes are arranged in one or more concentric bilayers. They can entrap both water and oil soluble substances in the inner aqueous phase and in the vesicular membrane, respectively. Niosomes are studied as an alternative to liposomes because they overcome the disadvantages associated with liposomes. The present study aimed to evaluate noisome formation from different surfactants and the encapsulation of amphotericin B as an amphiphilic model drug. Niosomes of Span 60®, Span 80®, Glyceryl monooleate, Dehydol® LS 2 HN (lauric alcohol 2EO) or Brij ®72 (Polyoxyethylene (2) Stearyl Ether) were prepared with the inclusion of cholesterol (ratio 1:1) by a modified ether injection technique. Two concentrations, 20 and 30 mM were studied. Span 60® and Span 80® 30mM formulations were the most stable and also the ones with higher entrapment capacity.
format Articulo
Articulo
author Salerno, Claudia
Chiappetta, Diego A.
Monteagudo, Ezequiel
Bregni, Carlos
author_facet Salerno, Claudia
Chiappetta, Diego A.
Monteagudo, Ezequiel
Bregni, Carlos
author_sort Salerno, Claudia
title Influence of surfactant structure in the encapsulation and stability of amphotericin B in niosomes
title_short Influence of surfactant structure in the encapsulation and stability of amphotericin B in niosomes
title_full Influence of surfactant structure in the encapsulation and stability of amphotericin B in niosomes
title_fullStr Influence of surfactant structure in the encapsulation and stability of amphotericin B in niosomes
title_full_unstemmed Influence of surfactant structure in the encapsulation and stability of amphotericin B in niosomes
title_sort influence of surfactant structure in the encapsulation and stability of amphotericin b in niosomes
publishDate 2011
url http://sedici.unlp.edu.ar/handle/10915/8366
http://www.latamjpharm.org/resumenes/30/9/LAJOP_30_9_1_10.pdf
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