Protection from arthritis and myositis in a mouse model of acute chikungunya virus disease by bindarit, an inhibitor of monocyte chemotactic protein-1 synthesis

Chikungunya virus (CHIKV) is associated with outbreaks of infectious rheumatic disease in humans. Using a mouse model of CHIKV arthritis and myositis, we show that tumor necrosis factor-α, interferon-γ, and monocyte chemotactic protein 1 (MCP-1) were dramatically induced in tissues from infected mic...

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Detalles Bibliográficos
Autores principales: Rulli, Néstor E., Rolph, Michael S., Srikiatkhachorn, Anon, Anantapreecha, Surapee, Guglielmotti, Angelo, Mahalingam, Suresh
Formato: Articulo
Lenguaje:Inglés
Publicado: 2011
Materias:
Ciencias Exactas
Ciencias Médicas
Chikungunya virus
arthritis
myositis
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/83659
Aporte de:
SEDICI (UNLP) de Universidad Nacional de La Plata
id I19-R120-10915-83659
record_format dspace
institution Universidad Nacional de La Plata
institution_str I-19
repository_str R-120
collection SEDICI (UNLP)
language Inglés
topic Ciencias Exactas
Ciencias Médicas
Chikungunya virus
arthritis
myositis
spellingShingle Ciencias Exactas
Ciencias Médicas
Chikungunya virus
arthritis
myositis
Rulli, Néstor E.
Rolph, Michael S.
Srikiatkhachorn, Anon
Anantapreecha, Surapee
Guglielmotti, Angelo
Mahalingam, Suresh
Protection from arthritis and myositis in a mouse model of acute chikungunya virus disease by bindarit, an inhibitor of monocyte chemotactic protein-1 synthesis
topic_facet Ciencias Exactas
Ciencias Médicas
Chikungunya virus
arthritis
myositis
description Chikungunya virus (CHIKV) is associated with outbreaks of infectious rheumatic disease in humans. Using a mouse model of CHIKV arthritis and myositis, we show that tumor necrosis factor-α, interferon-γ, and monocyte chemotactic protein 1 (MCP-1) were dramatically induced in tissues from infected mice. The same factors were detected in the serum of patients with CHIKV-induced polyarthralgia and polyarthritis, with MCP-1 levels being particularly elevated. Bindarit (MCP inhibitor) treatment ameliorated CHIKV disease in mice. Histological analysis of muscle and joint tissues showed a reduction in inflammatory infiltrate in infectedmice treated with bindarit. These results suggest that bindarit may be useful in treating CHIKV-induced arthritides in humans.
format Articulo
Articulo
author Rulli, Néstor E.
Rolph, Michael S.
Srikiatkhachorn, Anon
Anantapreecha, Surapee
Guglielmotti, Angelo
Mahalingam, Suresh
author_facet Rulli, Néstor E.
Rolph, Michael S.
Srikiatkhachorn, Anon
Anantapreecha, Surapee
Guglielmotti, Angelo
Mahalingam, Suresh
author_sort Rulli, Néstor E.
title Protection from arthritis and myositis in a mouse model of acute chikungunya virus disease by bindarit, an inhibitor of monocyte chemotactic protein-1 synthesis
title_short Protection from arthritis and myositis in a mouse model of acute chikungunya virus disease by bindarit, an inhibitor of monocyte chemotactic protein-1 synthesis
title_full Protection from arthritis and myositis in a mouse model of acute chikungunya virus disease by bindarit, an inhibitor of monocyte chemotactic protein-1 synthesis
title_fullStr Protection from arthritis and myositis in a mouse model of acute chikungunya virus disease by bindarit, an inhibitor of monocyte chemotactic protein-1 synthesis
title_full_unstemmed Protection from arthritis and myositis in a mouse model of acute chikungunya virus disease by bindarit, an inhibitor of monocyte chemotactic protein-1 synthesis
title_sort protection from arthritis and myositis in a mouse model of acute chikungunya virus disease by bindarit, an inhibitor of monocyte chemotactic protein-1 synthesis
publishDate 2011
url http://sedici.unlp.edu.ar/handle/10915/83659
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