Solution thermodynamics of Ibuprofen in aqueous media at pH 1.2 and 6.8

Based on van't Hoff and Gibbs equations, thermodynamic functions Gibbs energy, enthalpy, and entropy of solution, mixing and solvation of ibuprofen in water at pH 1.2 and 6.8, were evaluated from solubility values determined at several temperatures. The solubility at pH 6.8 and 298.15 K was alm...

Descripción completa

Guardado en:
Detalles Bibliográficos
Autores principales: Aragón, Diana M., Rosas, Jaiver E., Martínez, Fleming
Formato: Articulo
Lenguaje:Inglés
Publicado: 2011
Materias:
Farmacia
Solubilidad
Ibuprofeno
Termodinámica
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/8365
http://www.latamjpharm.org/resumenes/30/9/LAJOP_30_9_1_9.pdf
Aporte de:
SEDICI (UNLP) de Universidad Nacional de La Plata
id I19-R120-10915-8365
record_format dspace
institution Universidad Nacional de La Plata
institution_str I-19
repository_str R-120
collection SEDICI (UNLP)
language Inglés
topic Farmacia
Solubilidad
Ibuprofeno
Termodinámica
spellingShingle Farmacia
Solubilidad
Ibuprofeno
Termodinámica
Aragón, Diana M.
Rosas, Jaiver E.
Martínez, Fleming
Solution thermodynamics of Ibuprofen in aqueous media at pH 1.2 and 6.8
topic_facet Farmacia
Solubilidad
Ibuprofeno
Termodinámica
description Based on van't Hoff and Gibbs equations, thermodynamic functions Gibbs energy, enthalpy, and entropy of solution, mixing and solvation of ibuprofen in water at pH 1.2 and 6.8, were evaluated from solubility values determined at several temperatures. The solubility at pH 6.8 and 298.15 K was almost thirty six fold higher with respect to pH 1.2. The enthalpies of solution were positive and greater for pH 6.8 whereas the entropy of solution was negative for pH 1.2 and positive for pH 6.8 finding a greater molecular organization at pH 1.2 after solution process. The results were discussed in terms of solute-solvent interactions
format Articulo
Articulo
author Aragón, Diana M.
Rosas, Jaiver E.
Martínez, Fleming
author_facet Aragón, Diana M.
Rosas, Jaiver E.
Martínez, Fleming
author_sort Aragón, Diana M.
title Solution thermodynamics of Ibuprofen in aqueous media at pH 1.2 and 6.8
title_short Solution thermodynamics of Ibuprofen in aqueous media at pH 1.2 and 6.8
title_full Solution thermodynamics of Ibuprofen in aqueous media at pH 1.2 and 6.8
title_fullStr Solution thermodynamics of Ibuprofen in aqueous media at pH 1.2 and 6.8
title_full_unstemmed Solution thermodynamics of Ibuprofen in aqueous media at pH 1.2 and 6.8
title_sort solution thermodynamics of ibuprofen in aqueous media at ph 1.2 and 6.8
publishDate 2011
url http://sedici.unlp.edu.ar/handle/10915/8365
http://www.latamjpharm.org/resumenes/30/9/LAJOP_30_9_1_9.pdf
work_keys_str_mv AT aragondianam solutionthermodynamicsofibuprofeninaqueousmediaatph12and68
AT rosasjaivere solutionthermodynamicsofibuprofeninaqueousmediaatph12and68
AT martinezfleming solutionthermodynamicsofibuprofeninaqueousmediaatph12and68
bdutipo_str Repositorios
_version_ 1764820488864923648

Ejemplares similares