Fructose rich diet-induced high plasminogen activator inhibitor-1 (PAI-1) production in the adult female rat: Protective effect of progesterone

The effect of progesterone (P4) on fructose rich diet (FRD) intake-induced metabolic, endocrine and parametrial adipose tissue (PMAT) dysfunctions was studied in the adult female rat. Sixty day-old rats were i.m. treated with oil alone (control, CT) or containing P4 (12 mg/kg). Rats ate Purina chow-...

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Autores principales: Castrogiovanni, Daniel, Alzamendi, Ana, Ongaro Gambino, Luisina, Giovambattista, Andrés, Gaillard, Rolf C., Spinedi, Eduardo
Formato: Articulo
Lenguaje:Inglés
Publicado: 2012
Materias:
Ciencias Exactas
Adipokines
Allostasis
Glucose tolerance
High carbohydrate diet
Insulin
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/83633
Aporte de:
SEDICI (UNLP) de Universidad Nacional de La Plata
id I19-R120-10915-83633
record_format dspace
institution Universidad Nacional de La Plata
institution_str I-19
repository_str R-120
collection SEDICI (UNLP)
language Inglés
topic Ciencias Exactas
Adipokines
Allostasis
Glucose tolerance
High carbohydrate diet
Insulin
spellingShingle Ciencias Exactas
Adipokines
Allostasis
Glucose tolerance
High carbohydrate diet
Insulin
Castrogiovanni, Daniel
Alzamendi, Ana
Ongaro Gambino, Luisina
Giovambattista, Andrés
Gaillard, Rolf C.
Spinedi, Eduardo
Fructose rich diet-induced high plasminogen activator inhibitor-1 (PAI-1) production in the adult female rat: Protective effect of progesterone
topic_facet Ciencias Exactas
Adipokines
Allostasis
Glucose tolerance
High carbohydrate diet
Insulin
description The effect of progesterone (P4) on fructose rich diet (FRD) intake-induced metabolic, endocrine and parametrial adipose tissue (PMAT) dysfunctions was studied in the adult female rat. Sixty day-old rats were i.m. treated with oil alone (control, CT) or containing P4 (12 mg/kg). Rats ate Purina chow-diet <i>ad libitum</i> throughout the entire experiment and, between 100 and 120 days of age drank <i>ad libitum</i> tap water alone (normal diet; CT-ND and P4-ND) or containing fructose (10% w/v; CT-FRD and P4-FRD). At age 120 days, animals were subjected to a glucose tolerance test or decapitated. Plasma concentrations of various biomarkers and PMAT gene abundance were monitored. P4-ND (vs. CT-ND) rats showed elevated circulating levels of lipids. CT-FRD rats displayed high (vs. CT-ND) plasma concentrations of lipids, leptin, adiponectin and plasminogen activator inhibitor-1 (PAI-1). Lipidemia and adiponectinemia were high (vs. P4-ND) in P4-FRD rats. Although P4 failed to prevent FRD-induced hyperleptinemia, it was fully protective on FRD-enhanced plasma PAI-1 levels. PMAT leptin and adiponectin mRNAs were high in CT-FRD and P4-FRD rats. While FRD enhanced PMAT PAI-1 mRNA abundance in CT rats, this effect was absent in P4 rats. Our study supports that a preceding P4-enriched milieu prevented the enhanced prothrombotic risk induced by FRD-elicited high PAI-1 production.
format Articulo
Articulo
author Castrogiovanni, Daniel
Alzamendi, Ana
Ongaro Gambino, Luisina
Giovambattista, Andrés
Gaillard, Rolf C.
Spinedi, Eduardo
author_facet Castrogiovanni, Daniel
Alzamendi, Ana
Ongaro Gambino, Luisina
Giovambattista, Andrés
Gaillard, Rolf C.
Spinedi, Eduardo
author_sort Castrogiovanni, Daniel
title Fructose rich diet-induced high plasminogen activator inhibitor-1 (PAI-1) production in the adult female rat: Protective effect of progesterone
title_short Fructose rich diet-induced high plasminogen activator inhibitor-1 (PAI-1) production in the adult female rat: Protective effect of progesterone
title_full Fructose rich diet-induced high plasminogen activator inhibitor-1 (PAI-1) production in the adult female rat: Protective effect of progesterone
title_fullStr Fructose rich diet-induced high plasminogen activator inhibitor-1 (PAI-1) production in the adult female rat: Protective effect of progesterone
title_full_unstemmed Fructose rich diet-induced high plasminogen activator inhibitor-1 (PAI-1) production in the adult female rat: Protective effect of progesterone
title_sort fructose rich diet-induced high plasminogen activator inhibitor-1 (pai-1) production in the adult female rat: protective effect of progesterone
publishDate 2012
url http://sedici.unlp.edu.ar/handle/10915/83633
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bdutipo_str Repositorios
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