Anti-inflammatory and gastric effects of D-002, aspirin and naproxen and their combined therapy in rats with cotton pellet-induced granuloma

D-002, a mixture of six beeswax alcohols, with gastroprotective and anti-inflammatory effects, was compared with naproxen, aspirin and their combined therapy in rats with cotton pellet granuloma. After pellet implantation, rats were randomized into seven groups, a vehicle control and treated with (m...

Descripción completa

Guardado en:
Detalles Bibliográficos
Autores principales: Molina, Vivian, Ravelo, Yazmin, Carbajal, Daisy, Más, Rosa, Arruzazabala, María de Lourdes
Formato: Articulo
Lenguaje:Inglés
Publicado: 2011
Materias:
Farmacia
Aspirina
Agentes Antiinflamatorios
Terapia Combinada
Naproxeno
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/8363
http://www.latamjpharm.org/resumenes/30/9/LAJOP_30_9_1_7.pdf
Aporte de:
SEDICI (UNLP) de Universidad Nacional de La Plata
id I19-R120-10915-8363
record_format dspace
institution Universidad Nacional de La Plata
institution_str I-19
repository_str R-120
collection SEDICI (UNLP)
language Inglés
topic Farmacia
Aspirina
Agentes Antiinflamatorios
Terapia Combinada
Naproxeno
spellingShingle Farmacia
Aspirina
Agentes Antiinflamatorios
Terapia Combinada
Naproxeno
Molina, Vivian
Ravelo, Yazmin
Carbajal, Daisy
Más, Rosa
Arruzazabala, María de Lourdes
Anti-inflammatory and gastric effects of D-002, aspirin and naproxen and their combined therapy in rats with cotton pellet-induced granuloma
topic_facet Farmacia
Aspirina
Agentes Antiinflamatorios
Terapia Combinada
Naproxeno
description D-002, a mixture of six beeswax alcohols, with gastroprotective and anti-inflammatory effects, was compared with naproxen, aspirin and their combined therapy in rats with cotton pellet granuloma. After pellet implantation, rats were randomized into seven groups, a vehicle control and treated with (mg/kg): D-002 (50 and 200), naproxen (10 and 25) and aspirin (150 and 300). Other group of implanted rats was randomized into six groups, vehicle control and treated with D-002 50, naproxen 10, aspirin 150, D-002 50 + aspirin 150, or D-002 50 + naproxen 10. Granuloma weights decreased with all treatments, the effects of the highest doses were 38 % (D-002), 42 % (naproxen) and 42 % (aspirin). The combinations were not greater than those of each monotherapy. Aspirin and naproxen, not D-002, induced gastric ulceration. D-002 + naproxen or aspirin significantly decreased ulcers by 69.8 % and 67.3 %, respectively. Then, D-002, aspirin and naproxen were similarly effective for reducing the cotton granuloma in rats. The combination therapies D-002 + naproxen or aspirin did not produce greater anti-inflammatory effects, but reduced the NSAIDs-induced gastrotoxicity.
format Articulo
Articulo
author Molina, Vivian
Ravelo, Yazmin
Carbajal, Daisy
Más, Rosa
Arruzazabala, María de Lourdes
author_facet Molina, Vivian
Ravelo, Yazmin
Carbajal, Daisy
Más, Rosa
Arruzazabala, María de Lourdes
author_sort Molina, Vivian
title Anti-inflammatory and gastric effects of D-002, aspirin and naproxen and their combined therapy in rats with cotton pellet-induced granuloma
title_short Anti-inflammatory and gastric effects of D-002, aspirin and naproxen and their combined therapy in rats with cotton pellet-induced granuloma
title_full Anti-inflammatory and gastric effects of D-002, aspirin and naproxen and their combined therapy in rats with cotton pellet-induced granuloma
title_fullStr Anti-inflammatory and gastric effects of D-002, aspirin and naproxen and their combined therapy in rats with cotton pellet-induced granuloma
title_full_unstemmed Anti-inflammatory and gastric effects of D-002, aspirin and naproxen and their combined therapy in rats with cotton pellet-induced granuloma
title_sort anti-inflammatory and gastric effects of d-002, aspirin and naproxen and their combined therapy in rats with cotton pellet-induced granuloma
publishDate 2011
url http://sedici.unlp.edu.ar/handle/10915/8363
http://www.latamjpharm.org/resumenes/30/9/LAJOP_30_9_1_7.pdf
work_keys_str_mv AT molinavivian antiinflammatoryandgastriceffectsofd002aspirinandnaproxenandtheircombinedtherapyinratswithcottonpelletinducedgranuloma
AT raveloyazmin antiinflammatoryandgastriceffectsofd002aspirinandnaproxenandtheircombinedtherapyinratswithcottonpelletinducedgranuloma
AT carbajaldaisy antiinflammatoryandgastriceffectsofd002aspirinandnaproxenandtheircombinedtherapyinratswithcottonpelletinducedgranuloma
AT masrosa antiinflammatoryandgastriceffectsofd002aspirinandnaproxenandtheircombinedtherapyinratswithcottonpelletinducedgranuloma
AT arruzazabalamariadelourdes antiinflammatoryandgastriceffectsofd002aspirinandnaproxenandtheircombinedtherapyinratswithcottonpelletinducedgranuloma
bdutipo_str Repositorios
_version_ 1764820488847097857

Ejemplares similares