Design, development and evaluation of immediate release gliclazide tablets

The aim of the current study was the design, development and optimization of oral immediate release solid dosage forms of gliclazide tablets, intended for rapid action within 30 min, formulated and optimized by in vitro drug release method comparing with reference tablet Diamicron (Servier Lab.). Fo...

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Autores principales: Mahjabeen, Sanjida, Alam, Khondoker D., Faisal, Muhammad, Begum, Nazma, Hossen, Farhad, Hossan, Md. S.
Formato: Articulo
Lenguaje:Inglés
Publicado: 2011
Materias:
Farmacia
Disolución
Gliclazida
Dureza
Sistemas de Liberación de Medicamentos
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/8360
http://www.latamjpharm.org/resumenes/30/9/LAJOP_30_9_1_4.pdf
Aporte de:
SEDICI (UNLP) de Universidad Nacional de La Plata
id I19-R120-10915-8360
record_format dspace
institution Universidad Nacional de La Plata
institution_str I-19
repository_str R-120
collection SEDICI (UNLP)
language Inglés
topic Farmacia
Disolución
Gliclazida
Dureza
Sistemas de Liberación de Medicamentos
spellingShingle Farmacia
Disolución
Gliclazida
Dureza
Sistemas de Liberación de Medicamentos
Mahjabeen, Sanjida
Alam, Khondoker D.
Faisal, Muhammad
Begum, Nazma
Hossen, Farhad
Hossan, Md. S.
Design, development and evaluation of immediate release gliclazide tablets
topic_facet Farmacia
Disolución
Gliclazida
Dureza
Sistemas de Liberación de Medicamentos
description The aim of the current study was the design, development and optimization of oral immediate release solid dosage forms of gliclazide tablets, intended for rapid action within 30 min, formulated and optimized by in vitro drug release method comparing with reference tablet Diamicron (Servier Lab.). For fast breakdown and rapid dissolution of tablets three different disintegrants (sodium starch glycolate, kollidone CL, and dried maize starch) were used with same percentage (2 %) in the formulations; sodium starch glycolate provide very fast release of gliclazide from tablets in pH 7.4. Two different compression methods, direct compression and wet granulation, were employed in the study. The in vitro drug release profile was better for directly compressed gliclazide tablets, but the flow properties of gliclazide were very poor, which causes high weight variation. Wet granulation method provided tablets of good physical parameters: two types of tablets with different hardness (8-10 kg/cm2 and 5-7 kg/cm2 ) were prepared to observe the effect of compressional forces on drug dissolution and the later one exhibits short disintegration time and rapid dissolution of gliclazide. Friability and weight variation were found within the acceptable range. Incorporation of anionic surfactant in combination with sodium starch glycolate or kollidone CL in the formulation the dissolution rate. In comparison with reference tablet, formulation containing 2 % sodium starch glycolate and 1 % sodium lauryl sulphate with other excipients as lactose, microcrystalline cellulose, povidone K-30, Mg stearate and colloidal silicon dioxide provide better dissolution. Shelf life of the formulated tablets were determined by utilizing stress condition (40 °C and 75 % Relative humidity for 3 months) and found more than 2.5 year in room condition.
format Articulo
Articulo
author Mahjabeen, Sanjida
Alam, Khondoker D.
Faisal, Muhammad
Begum, Nazma
Hossen, Farhad
Hossan, Md. S.
author_facet Mahjabeen, Sanjida
Alam, Khondoker D.
Faisal, Muhammad
Begum, Nazma
Hossen, Farhad
Hossan, Md. S.
author_sort Mahjabeen, Sanjida
title Design, development and evaluation of immediate release gliclazide tablets
title_short Design, development and evaluation of immediate release gliclazide tablets
title_full Design, development and evaluation of immediate release gliclazide tablets
title_fullStr Design, development and evaluation of immediate release gliclazide tablets
title_full_unstemmed Design, development and evaluation of immediate release gliclazide tablets
title_sort design, development and evaluation of immediate release gliclazide tablets
publishDate 2011
url http://sedici.unlp.edu.ar/handle/10915/8360
http://www.latamjpharm.org/resumenes/30/9/LAJOP_30_9_1_4.pdf
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