Dissolution, HSPM, PXRD, DSC studies on gastro retentive multi-particulates of metformin hydrochloride for the treatment of diabetes using gelucire

Metformin hydrochloride (MH), an important drug in the treatment of type II diabetes mellitus, requires multiple administration in 500-1500 mg doses/day. Sustained release gastro retentive multiparticulates of MH were prepared by dispersing drug in melted gelucire 39/01 and 43/01 using the melt gran...

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Autores principales: Upadhyay, Prashant, Pandit, Jayant K.
Formato: Articulo
Lenguaje:Inglés
Publicado: 2011
Materias:
Farmacia
Rastreo Diferencial de Calorimetría
Microscopía de Polarización
Metformina
Difracción de Rayos X
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/8358
http://www.latamjpharm.org/resumenes/30/9/LAJOP_30_9_1_2.pdf
Aporte de:
SEDICI (UNLP) de Universidad Nacional de La Plata
id I19-R120-10915-8358
record_format dspace
institution Universidad Nacional de La Plata
institution_str I-19
repository_str R-120
collection SEDICI (UNLP)
language Inglés
topic Farmacia
Rastreo Diferencial de Calorimetría
Microscopía de Polarización
Metformina
Difracción de Rayos X
spellingShingle Farmacia
Rastreo Diferencial de Calorimetría
Microscopía de Polarización
Metformina
Difracción de Rayos X
Upadhyay, Prashant
Pandit, Jayant K.
Dissolution, HSPM, PXRD, DSC studies on gastro retentive multi-particulates of metformin hydrochloride for the treatment of diabetes using gelucire
topic_facet Farmacia
Rastreo Diferencial de Calorimetría
Microscopía de Polarización
Metformina
Difracción de Rayos X
description Metformin hydrochloride (MH), an important drug in the treatment of type II diabetes mellitus, requires multiple administration in 500-1500 mg doses/day. Sustained release gastro retentive multiparticulates of MH were prepared by dispersing drug in melted gelucire 39/01 and 43/01 using the melt granulation technique. Hot stage polarized microscopy, powder X-ray diffraction and differential scanning calorimetry thermograms were conducted to test crystallinity of MH and significant decrease in crystallinity was found. The percent drug entrapment in matrices was around 99.8 %. The multi-particulates demonstrated favorable in vitro floating ability for 11 h. Evaluation for in vitro drug release data analysis was performed using PCP-Disso software. Prepared formulations followed zero order kinetics and drug release mechanism was anomalous diffusion controlled. The combination of ethylcellulose, methylcellulose and microcrystalline cellulose with gelucire were noted for release of drug, floatability and consistency for optimized formulation. It was concluded that matrices of gelucire 39/01 and 43/01 may serve as effective carriers for highly water-soluble drugs for controlled delivery as compared to release profile with marketed sustained release product
format Articulo
Articulo
author Upadhyay, Prashant
Pandit, Jayant K.
author_facet Upadhyay, Prashant
Pandit, Jayant K.
author_sort Upadhyay, Prashant
title Dissolution, HSPM, PXRD, DSC studies on gastro retentive multi-particulates of metformin hydrochloride for the treatment of diabetes using gelucire
title_short Dissolution, HSPM, PXRD, DSC studies on gastro retentive multi-particulates of metformin hydrochloride for the treatment of diabetes using gelucire
title_full Dissolution, HSPM, PXRD, DSC studies on gastro retentive multi-particulates of metformin hydrochloride for the treatment of diabetes using gelucire
title_fullStr Dissolution, HSPM, PXRD, DSC studies on gastro retentive multi-particulates of metformin hydrochloride for the treatment of diabetes using gelucire
title_full_unstemmed Dissolution, HSPM, PXRD, DSC studies on gastro retentive multi-particulates of metformin hydrochloride for the treatment of diabetes using gelucire
title_sort dissolution, hspm, pxrd, dsc studies on gastro retentive multi-particulates of metformin hydrochloride for the treatment of diabetes using gelucire
publishDate 2011
url http://sedici.unlp.edu.ar/handle/10915/8358
http://www.latamjpharm.org/resumenes/30/9/LAJOP_30_9_1_2.pdf
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bdutipo_str Repositorios
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