In vitro cytotoxic screening of coumarins

This study reports the cytotoxicity screening of 33 coumarins in a panel of human tumor cell lines (Caco-2: human colorectal adenocarcinoma, HCT-8: human ileocecal adenocarcinoma, and HEp-2: human larynx epidermoid carcinoma). The classic MTT assay was employed to evaluate the influence of samples o...

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Detalles Bibliográficos
Autores principales:	Montagner, Cristina, Savi, Luciane A., Silva, Izabella T., Kratz, Jadel M., Smânia, Elza F. A., Monache, Franco D., Smânia Junior, Artur, Simões, Cláudia Maria Oliveira
Formato:	Articulo
Lenguaje:	Inglés
Publicado:	2011
Materias:	Farmacia Pruebas Inmunológicas de Citotoxicidad Cumarinas
Acceso en línea:	http://sedici.unlp.edu.ar/handle/10915/8357 http://www.latamjpharm.org/resumenes/30/9/LAJOP_30_9_1_1.pdf
Aporte de:	SEDICI (UNLP) de Universidad Nacional de La Plata

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record_format	dspace
institution	Universidad Nacional de La Plata
institution_str	I-19
repository_str	R-120
collection	SEDICI (UNLP)
language	Inglés
topic	Farmacia Pruebas Inmunológicas de Citotoxicidad Cumarinas
spellingShingle	Farmacia Pruebas Inmunológicas de Citotoxicidad Cumarinas Montagner, Cristina Savi, Luciane A. Silva, Izabella T. Kratz, Jadel M. Smânia, Elza F. A. Monache, Franco D. Smânia Junior, Artur Simões, Cláudia Maria Oliveira In vitro cytotoxic screening of coumarins
topic_facet	Farmacia Pruebas Inmunológicas de Citotoxicidad Cumarinas
description	This study reports the cytotoxicity screening of 33 coumarins in a panel of human tumor cell lines (Caco-2: human colorectal adenocarcinoma, HCT-8: human ileocecal adenocarcinoma, and HEp-2: human larynx epidermoid carcinoma). The classic MTT assay was employed to evaluate the influence of samples on cellular viability. Following continuous incubation with cells for 72 h, all tested coumarins exhibited CC50 values ≥ 0.34 mM for all three cell lines. These findings indicate that all samples were not able to reduce the viability of tumor cell lines used in this study in clinically relevant concentrations. Some structure-activity relationships were established and could be used for the synthesis of derivatives with improved cytotoxic potential.
format	Articulo Articulo
author	Montagner, Cristina Savi, Luciane A. Silva, Izabella T. Kratz, Jadel M. Smânia, Elza F. A. Monache, Franco D. Smânia Junior, Artur Simões, Cláudia Maria Oliveira
author_facet	Montagner, Cristina Savi, Luciane A. Silva, Izabella T. Kratz, Jadel M. Smânia, Elza F. A. Monache, Franco D. Smânia Junior, Artur Simões, Cláudia Maria Oliveira
author_sort	Montagner, Cristina
title	In vitro cytotoxic screening of coumarins
title_short	In vitro cytotoxic screening of coumarins
title_full	In vitro cytotoxic screening of coumarins
title_fullStr	In vitro cytotoxic screening of coumarins
title_full_unstemmed	In vitro cytotoxic screening of coumarins
title_sort	in vitro cytotoxic screening of coumarins
publishDate	2011
url	http://sedici.unlp.edu.ar/handle/10915/8357 http://www.latamjpharm.org/resumenes/30/9/LAJOP_30_9_1_1.pdf
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bdutipo_str	Repositorios
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In vitro cytotoxic screening of coumarins

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