Single RP-HPLC method for simultaneous estimation of pioglitazone, glibenclamide and glibenclamide impurities from a combination drug product

A simple reversed phase HPLC method was developed for simultaneous estimation of pioglitazone, glibenclamide, and glibenclamide impurities A and B from a combination drug product. The drugs and impurities are well separated using a reverse phase liquid chromatography with C-8 column. The isocratic m...

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Detalles Bibliográficos
Autores principales:	Elango, Kuppanagounder Pitchaimuthu, Karunakaran, Kulandaivelu, Navaneethan, Gurusamy
Formato:	Articulo Comunicacion
Lenguaje:	Inglés
Publicado:	2011
Materias:	Farmacia Combinación de Medicamentos RP-HPLC; pioglitazone; glibenclamide; validation; impurities Control de Calidad Cromatografía Liquida Estudios de Validación
Acceso en línea:	http://sedici.unlp.edu.ar/handle/10915/8351 http://www.latamjpharm.org/resumenes/30/8/LAJOP_30_8_2_3.pdf
Aporte de:	SEDICI (UNLP) de Universidad Nacional de La Plata

id	I19-R120-10915-8351
record_format	dspace
institution	Universidad Nacional de La Plata
institution_str	I-19
repository_str	R-120
collection	SEDICI (UNLP)
language	Inglés
topic	Farmacia Combinación de Medicamentos RP-HPLC; pioglitazone; glibenclamide; validation; impurities Control de Calidad Cromatografía Liquida Estudios de Validación
spellingShingle	Farmacia Combinación de Medicamentos RP-HPLC; pioglitazone; glibenclamide; validation; impurities Control de Calidad Cromatografía Liquida Estudios de Validación Elango, Kuppanagounder Pitchaimuthu Karunakaran, Kulandaivelu Navaneethan, Gurusamy Single RP-HPLC method for simultaneous estimation of pioglitazone, glibenclamide and glibenclamide impurities from a combination drug product
topic_facet	Farmacia Combinación de Medicamentos RP-HPLC; pioglitazone; glibenclamide; validation; impurities Control de Calidad Cromatografía Liquida Estudios de Validación
description	A simple reversed phase HPLC method was developed for simultaneous estimation of pioglitazone, glibenclamide, and glibenclamide impurities A and B from a combination drug product. The drugs and impurities are well separated using a reverse phase liquid chromatography with C-8 column. The isocratic mobile phase comprising phosphate buffer (pH 5.0): acetonitrile in the ratio of 75:25 (v/v) at 1.0 mL/min flow rate, UV detection at 250 nm, column temperature was maintained at 30 °C and the injection volume was used 150 μL. The proposed method was validated according to the ICH guidelines and proved suitable for routine analysis and quality control testing of these drugs in pharmaceutical preparations.
format	Articulo Comunicacion
author	Elango, Kuppanagounder Pitchaimuthu Karunakaran, Kulandaivelu Navaneethan, Gurusamy
author_facet	Elango, Kuppanagounder Pitchaimuthu Karunakaran, Kulandaivelu Navaneethan, Gurusamy
author_sort	Elango, Kuppanagounder Pitchaimuthu
title	Single RP-HPLC method for simultaneous estimation of pioglitazone, glibenclamide and glibenclamide impurities from a combination drug product
title_short	Single RP-HPLC method for simultaneous estimation of pioglitazone, glibenclamide and glibenclamide impurities from a combination drug product
title_full	Single RP-HPLC method for simultaneous estimation of pioglitazone, glibenclamide and glibenclamide impurities from a combination drug product
title_fullStr	Single RP-HPLC method for simultaneous estimation of pioglitazone, glibenclamide and glibenclamide impurities from a combination drug product
title_full_unstemmed	Single RP-HPLC method for simultaneous estimation of pioglitazone, glibenclamide and glibenclamide impurities from a combination drug product
title_sort	single rp-hplc method for simultaneous estimation of pioglitazone, glibenclamide and glibenclamide impurities from a combination drug product
publishDate	2011
url	http://sedici.unlp.edu.ar/handle/10915/8351 http://www.latamjpharm.org/resumenes/30/8/LAJOP_30_8_2_3.pdf
work_keys_str_mv	AT elangokuppanagounderpitchaimuthu singlerphplcmethodforsimultaneousestimationofpioglitazoneglibenclamideandglibenclamideimpuritiesfromacombinationdrugproduct AT karunakarankulandaivelu singlerphplcmethodforsimultaneousestimationofpioglitazoneglibenclamideandglibenclamideimpuritiesfromacombinationdrugproduct AT navaneethangurusamy singlerphplcmethodforsimultaneousestimationofpioglitazoneglibenclamideandglibenclamideimpuritiesfromacombinationdrugproduct
bdutipo_str	Repositorios
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Single RP-HPLC method for simultaneous estimation of pioglitazone, glibenclamide and glibenclamide impurities from a combination drug product

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