Glycyrrhizic acid-phospholipid complex: preparation process optimization and therapeutic and pharmacokinetic evaluation in rats
The purpose of the present study was to prepare glycyrrhizic acid-phospholipid complex (GL-PLC) as to improve the oral bioavailability of glycyrrhizic acid (GL), enhance the drug efficacy and reduce the side effects. The uniform experimental design approach was utilized for the process optimization...
Guardado en:
| Autores principales: | , , , , , |
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| Formato: | Articulo |
| Lenguaje: | Inglés |
| Publicado: |
2011
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| Materias: | |
| Acceso en línea: | http://sedici.unlp.edu.ar/handle/10915/8348 http://www.latamjpharm.org/resumenes/30/8/LAJOP_30_8_1_26.pdf |
| Aporte de: |
| id |
I19-R120-10915-8348 |
|---|---|
| record_format |
dspace |
| institution |
Universidad Nacional de La Plata |
| institution_str |
I-19 |
| repository_str |
R-120 |
| collection |
SEDICI (UNLP) |
| language |
Inglés |
| topic |
Farmacia anti-inflammatory activity; glycyrrhizic acid-phospholipid complex; oral bioavailability; pharmacokinetics evaluación comparativa de resultados |
| spellingShingle |
Farmacia anti-inflammatory activity; glycyrrhizic acid-phospholipid complex; oral bioavailability; pharmacokinetics evaluación comparativa de resultados Liu, Zhen Chen, Hong Qiang, Qianqian Bai, Shufang Gao, Wenyuan Zhang, Jingze Glycyrrhizic acid-phospholipid complex: preparation process optimization and therapeutic and pharmacokinetic evaluation in rats |
| topic_facet |
Farmacia anti-inflammatory activity; glycyrrhizic acid-phospholipid complex; oral bioavailability; pharmacokinetics evaluación comparativa de resultados |
| description |
The purpose of the present study was to prepare glycyrrhizic acid-phospholipid complex (GL-PLC) as to improve the oral bioavailability of glycyrrhizic acid (GL), enhance the drug efficacy and reduce the side effects. The uniform experimental design approach was utilized for the process optimization in order to obtain the satisfactory complex. The results of comparison between GL-PLC and free GL indicated that the anti-inflammatory activity of the phospholipid complex was significantly higher than that of free GL at the same dose. The results of pharmacokinetic study displayed that the plasma concentration of glycyrrhetic acid, the metabolite of GL in vivo, increased after oral administration of GL-PLC. The Cmax of GL-PLC was 2.14 times higher than that of free glycyrrhizic acid, while the AUC of GL-PLC was 1.74 times higher than that of free GL. The results proved that GL-PLC improved the lipophilic property of GL, increased the bioavailability and anti-inflammatory activity. |
| format |
Articulo Articulo |
| author |
Liu, Zhen Chen, Hong Qiang, Qianqian Bai, Shufang Gao, Wenyuan Zhang, Jingze |
| author_facet |
Liu, Zhen Chen, Hong Qiang, Qianqian Bai, Shufang Gao, Wenyuan Zhang, Jingze |
| author_sort |
Liu, Zhen |
| title |
Glycyrrhizic acid-phospholipid complex: preparation process optimization and therapeutic and pharmacokinetic evaluation in rats |
| title_short |
Glycyrrhizic acid-phospholipid complex: preparation process optimization and therapeutic and pharmacokinetic evaluation in rats |
| title_full |
Glycyrrhizic acid-phospholipid complex: preparation process optimization and therapeutic and pharmacokinetic evaluation in rats |
| title_fullStr |
Glycyrrhizic acid-phospholipid complex: preparation process optimization and therapeutic and pharmacokinetic evaluation in rats |
| title_full_unstemmed |
Glycyrrhizic acid-phospholipid complex: preparation process optimization and therapeutic and pharmacokinetic evaluation in rats |
| title_sort |
glycyrrhizic acid-phospholipid complex: preparation process optimization and therapeutic and pharmacokinetic evaluation in rats |
| publishDate |
2011 |
| url |
http://sedici.unlp.edu.ar/handle/10915/8348 http://www.latamjpharm.org/resumenes/30/8/LAJOP_30_8_1_26.pdf |
| work_keys_str_mv |
AT liuzhen glycyrrhizicacidphospholipidcomplexpreparationprocessoptimizationandtherapeuticandpharmacokineticevaluationinrats AT chenhong glycyrrhizicacidphospholipidcomplexpreparationprocessoptimizationandtherapeuticandpharmacokineticevaluationinrats AT qiangqianqian glycyrrhizicacidphospholipidcomplexpreparationprocessoptimizationandtherapeuticandpharmacokineticevaluationinrats AT baishufang glycyrrhizicacidphospholipidcomplexpreparationprocessoptimizationandtherapeuticandpharmacokineticevaluationinrats AT gaowenyuan glycyrrhizicacidphospholipidcomplexpreparationprocessoptimizationandtherapeuticandpharmacokineticevaluationinrats AT zhangjingze glycyrrhizicacidphospholipidcomplexpreparationprocessoptimizationandtherapeuticandpharmacokineticevaluationinrats |
| bdutipo_str |
Repositorios |
| _version_ |
1764820488659402754 |