Curcumin inhibits proliferation and metastasis of human hypopharyngeal carcinoma cells

The present study was designed to investigate the effects of curcumin, a natural product derived from turmeric of the herb Curcuma longa, on proliferation, metastasis of FaDu cells, and the relevant mechanisms. Results showed that curcumin could inhibit the proliferation, induce apoptosis of FaDu ce...

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Detalles Bibliográficos
Autores principales: Wang, Haibo, Li, Jianfeng, Bai, Xiaohui, Lu, Sumei, Han, Yuechen, Fan, Zhaomin, Liu, Wenwen, Xu, Wei
Formato: Articulo
Lenguaje:Inglés
Publicado: 2011
Materias:
Farmacia
Muerte Celular
hypopharyngeal carcinoma; curcumin; proliferation; apoptosis; metastasis
Plantas Medicinales
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/8347
http://www.latamjpharm.org/resumenes/30/8/LAJOP_30_8_1_25.pdf
Aporte de:
SEDICI (UNLP) de Universidad Nacional de La Plata
id I19-R120-10915-8347
record_format dspace
institution Universidad Nacional de La Plata
institution_str I-19
repository_str R-120
collection SEDICI (UNLP)
language Inglés
topic Farmacia
Muerte Celular
hypopharyngeal carcinoma; curcumin; proliferation; apoptosis; metastasis
Plantas Medicinales
spellingShingle Farmacia
Muerte Celular
hypopharyngeal carcinoma; curcumin; proliferation; apoptosis; metastasis
Plantas Medicinales
Wang, Haibo
Li, Jianfeng
Bai, Xiaohui
Lu, Sumei
Han, Yuechen
Fan, Zhaomin
Liu, Wenwen
Xu, Wei
Curcumin inhibits proliferation and metastasis of human hypopharyngeal carcinoma cells
topic_facet Farmacia
Muerte Celular
hypopharyngeal carcinoma; curcumin; proliferation; apoptosis; metastasis
Plantas Medicinales
description The present study was designed to investigate the effects of curcumin, a natural product derived from turmeric of the herb Curcuma longa, on proliferation, metastasis of FaDu cells, and the relevant mechanisms. Results showed that curcumin could inhibit the proliferation, induce apoptosis of FaDu cells, and arrest the cell-cycle at S phases in a dose-dependent manner. The ability of FaDu cells in migration and invasion was declined significantly after treated with curcumin. Additionally, caspase-9 and caspase-3 were activated, and the expression of Bax and E-cadherin were up-regulated, whereas, the expressions of Bcl-2, MMP-2 and MMP-9 were down-regulated in response to curcumin. In conclusion, these data suggested that curcumin can effectively suppress proliferation and inhibit the invasion and metastasis of FaDu cells via the induction of apoptosis, the blockage of cell cycle as well as the modulation of certain relevant genes.
format Articulo
Articulo
author Wang, Haibo
Li, Jianfeng
Bai, Xiaohui
Lu, Sumei
Han, Yuechen
Fan, Zhaomin
Liu, Wenwen
Xu, Wei
author_facet Wang, Haibo
Li, Jianfeng
Bai, Xiaohui
Lu, Sumei
Han, Yuechen
Fan, Zhaomin
Liu, Wenwen
Xu, Wei
author_sort Wang, Haibo
title Curcumin inhibits proliferation and metastasis of human hypopharyngeal carcinoma cells
title_short Curcumin inhibits proliferation and metastasis of human hypopharyngeal carcinoma cells
title_full Curcumin inhibits proliferation and metastasis of human hypopharyngeal carcinoma cells
title_fullStr Curcumin inhibits proliferation and metastasis of human hypopharyngeal carcinoma cells
title_full_unstemmed Curcumin inhibits proliferation and metastasis of human hypopharyngeal carcinoma cells
title_sort curcumin inhibits proliferation and metastasis of human hypopharyngeal carcinoma cells
publishDate 2011
url http://sedici.unlp.edu.ar/handle/10915/8347
http://www.latamjpharm.org/resumenes/30/8/LAJOP_30_8_1_25.pdf
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