Regression of hypertensive myocardial fibrosis by Na+/H+ exchange inhibition

We have recently reported that the inhibition of the Na<SUP>+</SUP>/H<SUP>+</SUP> exchanger (NHE) during 1 month in spontaneously hypertensive rats (SHR) is followed by regression of cardiomyocyte hypertrophy but not of myocardial fibrosis. The aim of this study was to evalua...

Descripción completa

Guardado en:
Detalles Bibliográficos
Autores principales: Cingolani, Horacio Eugenio, Rebolledo, Oscar Remigio, Portiansky, Enrique Leo, Pérez, Néstor Gustavo, Camilión de Hurtado, María Cristina
Formato: Articulo
Lenguaje:Inglés
Publicado: 2003
Materias:
Ciencias Médicas
Extracellular matrix
Fibrosis
Myocardium
Signal transduction
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/83467
Aporte de:
SEDICI (UNLP) de Universidad Nacional de La Plata
id I19-R120-10915-83467
record_format dspace
institution Universidad Nacional de La Plata
institution_str I-19
repository_str R-120
collection SEDICI (UNLP)
language Inglés
topic Ciencias Médicas
Extracellular matrix
Fibrosis
Myocardium
Signal transduction
spellingShingle Ciencias Médicas
Extracellular matrix
Fibrosis
Myocardium
Signal transduction
Cingolani, Horacio Eugenio
Rebolledo, Oscar Remigio
Portiansky, Enrique Leo
Pérez, Néstor Gustavo
Camilión de Hurtado, María Cristina
Regression of hypertensive myocardial fibrosis by Na+/H+ exchange inhibition
topic_facet Ciencias Médicas
Extracellular matrix
Fibrosis
Myocardium
Signal transduction
description We have recently reported that the inhibition of the Na<SUP>+</SUP>/H<SUP>+</SUP> exchanger (NHE) during 1 month in spontaneously hypertensive rats (SHR) is followed by regression of cardiomyocyte hypertrophy but not of myocardial fibrosis. The aim of this study was to evaluate whether a treatment of longer duration could reduce myocardial fibrosis and stiffness. SHR received 3.0 mg/kg per day of the specific NHE-1 inhibitor cariporide; the effect on cardiomyocyte cross-sectional area, myocardial collagen volume fraction, collagen synthesis, and myocardial stiffness (length-tension relation in left papillary muscles) was evaluated at several time points (after 1, 2, or 3 months). A slight decrease of ≈5 mm Hg in systolic blood pressure was observed after 1 month of treatment with no further changes. After 2 and 3 months of treatment, the size of cardiomyocytes remained within normal values and myocardial fibrosis progressively decreased to normal level. Accordingly, myocardial stiffness and the serum levels of the carboxyterminal propeptide of procollagen type I, a marker of collagen type I synthesis, were normalized after 3 months. Left ventricular weight decreased from 910±43 (in untreated SHR) to 781±21 mg (treated SHR) after 3 months of treatment. No difference in body weight between treated and untreated SHR was observed after this period of treatment. The present data allow us to conclude that in the SHR the administration of an NHE-1 inhibitor for 2 or 3 months leads to the normalization of collagen type I synthesis, myocardial collagen volume fraction, and stiffness.
format Articulo
Articulo
author Cingolani, Horacio Eugenio
Rebolledo, Oscar Remigio
Portiansky, Enrique Leo
Pérez, Néstor Gustavo
Camilión de Hurtado, María Cristina
author_facet Cingolani, Horacio Eugenio
Rebolledo, Oscar Remigio
Portiansky, Enrique Leo
Pérez, Néstor Gustavo
Camilión de Hurtado, María Cristina
author_sort Cingolani, Horacio Eugenio
title Regression of hypertensive myocardial fibrosis by Na+/H+ exchange inhibition
title_short Regression of hypertensive myocardial fibrosis by Na+/H+ exchange inhibition
title_full Regression of hypertensive myocardial fibrosis by Na+/H+ exchange inhibition
title_fullStr Regression of hypertensive myocardial fibrosis by Na+/H+ exchange inhibition
title_full_unstemmed Regression of hypertensive myocardial fibrosis by Na+/H+ exchange inhibition
title_sort regression of hypertensive myocardial fibrosis by na+/h+ exchange inhibition
publishDate 2003
url http://sedici.unlp.edu.ar/handle/10915/83467
work_keys_str_mv AT cingolanihoracioeugenio regressionofhypertensivemyocardialfibrosisbynahexchangeinhibition
AT rebolledooscarremigio regressionofhypertensivemyocardialfibrosisbynahexchangeinhibition
AT portianskyenriqueleo regressionofhypertensivemyocardialfibrosisbynahexchangeinhibition
AT pereznestorgustavo regressionofhypertensivemyocardialfibrosisbynahexchangeinhibition
AT camiliondehurtadomariacristina regressionofhypertensivemyocardialfibrosisbynahexchangeinhibition
bdutipo_str Repositorios
_version_ 1764820488645771267

Ejemplares similares